Association of N-acetyltransferase-2 Polymorphism with Antituberculosis Induced Hepatotoxicity: A Meta-analysis

Title:Association of N-acetyltransferase-2 Polymorphism with Antituberculosis Induced Hepatotoxicity: A Meta-analysis

Volume: 18 Issue: 2

Author(s): Nur Farhana Mohamed Noor, Teh Lay Kek*, Mohd Arif Mohd Zim, Zamzurina Abu Bakar, Noor Izyani Zakaria, Muhammad Imran Lailanor and Mohd Zaki Salleh

Affiliation:

• Integrative Pharmacogenomics Institute (iPROMISE), Universiti Teknologi MARA, Selangor Branch, Puncak Alam Campus, Selangor, Malaysia
• Faculty Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia

Keywords: Antituberculosis, hepatotoxicity, slow acetylator, NAT2 polymorphism, meta-analysis, personalized medicine, pharmacogenomic.

Abstract: Background: N-acetyltransferase (NAT2) polymorphisms were reported to play important roles in Antituberculosis-Induced Hepatotoxicity (ATDIH). However, the allelic types with increased risks for ATDIH were inconsistent as most studies are of a small sample size.

Objective: The objective of the study was to conduct a meta-analysis to identify NAT2 alleles associated with increased risks of ATDIH.

Methods: Studies reported on NAT2 polymorphism with the risk of ATDIH were searched systematically in PubMed, Scopus, and the World of Sciences. Studies were included if they fulfilled the inclusion criteria and excluded accordingly. Quality assessments were done using Newcastle- Ottawa Score. Statistical analysis was performed using Review Manager version 5.3. Cochrane Q-statistic test and I2 statistic were used to assess and quantify heterogeneity.

Results: A total of 12 studies involving 580 cases and 3129 controls were included. NAT2 polymorphism was significantly associated with the risk of ATDIH with an Odd Ratio (OR) of 2.76 (1.86 – 4.10, 95% CI). Among the slow acetylators genotypes, NAT2*5/*7 carry the highest risk associated with ATDIH.

Conclusion: NAT2 polymorphism was significantly associated with ATDIH.

Cite this article as:

Noor Farhana Mohamed Nur , Kek Lay Teh *, Zim Arif Mohd Mohd , Bakar Abu Zamzurina , Zakaria Izyani Noor , Lailanor Imran Muhammad and Salleh Zaki Mohd , Association of N-acetyltransferase-2 Polymorphism with Antituberculosis Induced Hepatotoxicity: A Meta-analysis, Current Pharmacogenomics and Personalized Medicine 2021; 18 (2) . https://dx.doi.org/10.2174/1875692118666210928170636