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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Dibromination of Cinnamamides with CBr4 Under Mild Conditions

Author(s): Zaigang Luo*, Shuai Liu, Chengtong Peng, Xiuxiu Wang and Xuemei Xu

Volume 19, Issue 1, 2022

Page: [59 - 63] Pages: 5

DOI: 10.2174/1570178618666210920114503

Price: $65

Abstract

A novel, mild and efficient protocol to synthesize dibrominated propanamides has been developed. The presented methodology provides several merits, such as easy-to-handle and stable brominated substrate, catalyst-free, additive-free, and facile experimental operation. The study on the preliminary mechanism indicated that a free radical pathway might be involved in the presented reaction.

Keywords: Dibromination, cinnamamides, CBr4, dibrominated propanamides, radical reaction, synthesis.

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