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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Review Article

Natural Inhibitors against Potential Targets of Cyclooxygenase, Lipoxygenase and Leukotrienes

Author(s): Rishita Dey, Sudatta Dey, Asmita Samadder, Anil Kumar Saxena* and Sisir Nandi*

Volume 25, Issue 14, 2022

Published on: 03 January, 2022

Page: [2341 - 2357] Pages: 17

DOI: 10.2174/1386207325666210917111847

Price: $65

Abstract

Background: Cyclooxygenase (COX) and Lipoxygenase (LOX) enzymes catalyze the production of pain mediators like Prostaglandins (PGs) and Leukotrienes (LTs), respectively from arachidonic acid.

Introduction: The COX and LOX enzyme modulators are responsible for the major PGs and LTs mediated complications like asthma, osteoarthritis, rheumatoid arthritis, cancer, Alzheimer’s disease, neuropathy and Cardiovascular Syndromes (CVS). Many synthetic Nonsteroidal Anti- Inflammatory Drugs (NSAIDs) used in the treatment have serious side effects like nausea, vomiting, hyperacidity, gastrointestinal ulcers, CVS, etc.

Methods: The natural inhibitors of pain mediators have great acceptance worldwide due to fewer side effects on long-term uses. The present review is an extensive study of the advantages of plantbased vs synthetic inhibitors.

Results: These natural COX and LOX inhibitors control inflammatory response without causing side-effect-related complicacy.

Conclusion: Therefore, the natural COX and LOX inhibitors may be used as alternative medicines for the management of pain and inflammation due to their less toxicity and resistivity.

Keywords: Pain and inflammation mediators, COX, LOX, leukotrienes (LTs), natural inhibitors, alternative medicine.

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