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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Methyl-linked Pyrazoles: Synthetic and Medicinal Perspective

Author(s): Tulika Sharma, Joginder Singh, Bijender Singh, Ramesh Kataria and Vinod Kumar*

Volume 22, Issue 5, 2022

Published on: 05 January, 2022

Page: [770 - 804] Pages: 35

DOI: 10.2174/1389557521666210914124914

Price: $65

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Abstract

Pyrazoles, an important and well-known class of the azole family, have been found to show a large number of applications in various fields, especially medicinal chemistry. Pyrazole derivatives, particularly methyl-substituted pyrazoles, have been reported as potent medicinal scaffolds that exhibit a wide spectrum of biological activities. The present review is an attempt to highlight the detailed synthetic approaches for methyl-substituted pyrazoles along with an in-depth analysis of their respective medical significances till March 2021. It is hoped that literature sum-up in the form of present review article would certainly be a great tool in assisting medicinal chemists in generating new leads possessing pyrazole nucleus with high efficacy and less microbial resistance.

Keywords: Pyrazoles, drug discovery, medicinal chemistry, organic synthesis, microbial resistance, NMR spectral characteristics.

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