The Roles of Signaling Pathways in Cardiac Regeneration

doi:10.2174/0929867328666210914115411
摘要

近年来，对心脏再生机制的了解急剧扩大。再生可以替代器官的缺失部分，这在动物物种中很常见。心脏通常被认为是具有终末发育的器官，在产后生命中没有可修复的潜力。然而，已经报道了心肌的一些内在再生能力，这为心血管疾病治疗开辟了新的途径。近几十年来，已经研究了用于心脏修复和再生的不同内源性机制。生存，增殖，炎症，血管生成，细胞 - 细胞通讯，心肌发生和抗衰老途径是在这方面研究的最重要机制。一些专注于心脏再生增殖诱导的体外和动物模型研究报告了有希望的结果。这些研究主要集中在促进增殖信号通路上，并展示了各种信号通路，如Wnt，PI3K / Akt，IGF-1，TGF-β，Hippo和VEGF信号传导心脏再生。因此，在本综述中，我们打算讨论心脏修复和再生中不同关键信号通路之间的联系。
关键词: 信号通路，心脏，再生，Wnt信号传导，缺口信号传导，VEGF信号传导，IGF-1信号传导。
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DOI https://dx.doi.org/10.2174/0929867328666210914115411	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

信号通路在心脏再生中的作用

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