Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Acanthospermum hispidum DC: An Updated Review on Phytochemistry and Biological Activities

Author(s): Ewelyn Cintya Felipe dos Santos, Janaina Carla Barbosa Machado, Magda Rhayanny Assunção Ferreira and Luiz Alberto Lira Soares*

Volume 22, Issue 5, 2022

Published on: 04 January, 2022

Page: [684 - 700] Pages: 17

DOI: 10.2174/1389557521666210913115651

Price: $65

Abstract

Background: Acanthospermum hispidum DC is a medicinal plant present in America, Africa, Australia, India, Hawaii, and Brazil. In Brazil, the species is used in the treatment of gastrointestinal, respiratory disorders and has expectorant action. In the literature, there are studies on the chemical composition of the species, with reports of the presence of alkaloids, flavonoids, hydrolyzable tannins, terpenes, and steroids. In addition, several studies have reported in vitro and in vivo studies that prove the biological properties of extracts and compounds isolated from different organs of the A. hispidum plant, including hepatoprotectors, antioxidants, antimicrobials and antiparasitic.

Objective: The objective of this review is to update the knowledge about the phytochemical, pharmacological and toxicity aspects of A. hispidum, and to contribute to the recognition of the species and direct new studies.

Methods: An extensive bibliographic search was conducted in different scientific databases.

Results: The presence of different chemical constituents in A. hispidum has been identified, among these constituents are flavonoids, tannins, terpenes, and steroids. Additionally, antimicrobial and antiparasitic activities were mainly attributed to the species, and other activities not previously described were presented, such as anticholinesterase, antioxidant, hepatoprotective, and hypoglycemic, all based on results of in vitro and in vivo studies. Finally, no reports of toxic effects were found in the in vitro and in vivo tests. After analyzing the articles, it was evidenced that other experiments with different models using animals are essential to evaluate the possible mechanisms of action of the extracts and compounds isolated of A. hispidum.

Conclusion: Therefore, this review may contribute to the recognition of the importance of A. hispidum and its potential as a medicinal plant and may also guide the conduct of future research regarding the constituents, biological activities, and toxicity of the species.

Keywords: Acanthospermum hispidum, bioactive constituents, medicinal plants, pharmacology, phytochemistry, toxicity.

Graphical Abstract

[2]
Silva, A.A.; Andrade, L.H.C. Utilização de espécies de Asteraceae por comunidades rurais do Nordeste do Brasil: Relatos em Camocim de São Félix, Pernambuco. Biotemas, 2013, 26(2), 93-104.
[http://dx.doi.org/10.5007/2175-7925.2013v26n2p93]
[3]
Chakraborty, A.K.; Gaikwad, A.V.; Singh, K.B. Phytopharmacological review on Acanthospermum hispidum. J. Appl. Pharm. Sci., 2012, 2(1), 144-148.
[4]
Araújo, L.B.D.C.; Silva, S.L.; Galvão, M.A.M.; Ferreira, M.R.A.; Araújo, E.L.; Randau, K.P.; Soares, L.A.L. Total phytosterol content in drug materials and extracts from roots of Acanthospermum hispidum by UV-VIS spectrophotometry. Braz. J. Pharmacog., 2013, 23(5), 736-742.
[http://dx.doi.org/10.1590/S0102-695X2013000500004]
[5]
Mihigo, S.O.; Ndombele, L.; Masesane, I.B.; Sichilongo, K. Preliminary GC-MS Profiling and Anti-bacterial activity Investigation of Acanthospermum hispidum DC (Asteraceae). Int. J. Chem. Aquat. Sci., 2015, 1(1), 1-10.
[10]
De Araújo, E.L.; Randau, K.P.; Sena-Filho, J.G.; Mendonça Pimentel, R.M.; Xavier, H.S. Acanthospermum hispidum DC (Asteraceae): Perspectives for a phytotherapeutic product. Braz. J. Pharmacog., 2008, 18(Suppl.), 777-784.
[http://dx.doi.org/10.1590/S0102-695X2008000500024]
[11]
Adepiti, A.O.; Adewunmi, C.O.; Agbedahunsi, J.M. Antitrichomonal activity of Acanthospermum hispidum DC (Asteraceae). Afr. J. Biotechnol., 2014, 13(11), 1303-1307.
[http://dx.doi.org/10.5897/AJB2013.13064]
[12]
Alva, M.; Popich, S.; Borkosky, S.; Cartagena, E.; Bardón, A. Bioactivity of the essential oil of an argentine collection of Acanthospermum hispidum (Asteraceae). Nat. Prod. Commun., 2012, 7(2), 245-248.
[http://dx.doi.org/10.1177/1934578X1200700235] [PMID: 22474971]
[13]
Basile, Y.A.; Djeneb, C.; Kiyinlma, C.; Noël, Z.G. Ethnobotanical study and comparison of antitrichophytic activity leaves of Aspila africana (PERS.) CD ADAMS VAR. AFRICANA, Ageratum conyzoides L. and Acanthospermum hispidum DC on the In Vitro Growth of Trichophyton mentagrophytes. Indo Am. J. Pharmaceut. Sci., 2018, 5(5), 4766-4773.
[14]
Basile, Y.A.; Guillaumme, Y.Y.; Djeneb, C.; Noël, Z.G. Botanical study, comparison of antifungal activity leaves of Aspilia africana (Pers.) CD Adams var. africana and Acanthospermum hispidum DC. on the in vitro growth of Cryptococcus neoformans and study of their toxicity on human cells HFF. Int. J. Innov. Appl. Stud., 2016, 17(3), 980-989.
[15]
Araújo, E.L.; Xavier, H.S.; Ferreira, C.P.; Randau, K.P.; Pimentel, R.M.M. Macro and microscopical identification of two Acanthospermum medicinal plants. J. Med. Plants Res., 2013, 7(35), 2606-2615.
[16]
Bhakshu, L.M.; Ratnam, K.V.; Raju, R.R. Anticandidal activity and phytochemical analysis of certain medicinal plants from Eastern Ghats, India. Indian J. Nat. Prod. Resour., 2016, 7(1), 25-31.
[17]
N’Do, J.Y-p.; Pare, D.; Hilou, A. Phytochemical and Chromatographic Screening of Extracts of Acanthospermum Hispidum DC (Asteraceae). Scholars Int. J. Chem. Mat. Sci., 2019, 2(7), 109-114.
[http://dx.doi.org/10.36348/sijcms.2019.v02i07.001]
[18]
Akah, P.A.; Onyeto, C.A.; Okafor, A. Antitussive properties of the root extract and fractions of Acanthospermum hispidum (L). Int. J. Pharmacol. Res., 2017, 7(1), 12-16.
[19]
Abubakar, A.; Sodipo, O.A.; Khan, I.Z.; Fugu, M.B.; Mamza, U.T.; Gulani, I.A. Phytochemical screening and in vitro antimicrobial activities of the leaf extract of Acanthospermum hispidum DC (Asteraceae). J. Plant Stud., 2015, 4(2), 1-8.
[http://dx.doi.org/10.5539/jps.v4n2p66]
[20]
Sharaibi, O.J.; Osuntogun, O.S. Ethnomedicinal information and phytochemical screening of medicinal plants used in the treatment of diarrhea in Lagos State, Nigeria. European J. Med. Plants, 2017, 19(4), 1-7.
[http://dx.doi.org/10.9734/EJMP/2017/26815]
[21]
Chika, A.; Onyebueke, D.C.; Bello, S.O. Phytochemical analysis and evaluation of antidiabetic effects in alloxan-induced diabetic rats treated with aqueous leaf extract of Acanthospermum hispidum. Afr. J. Biomed. Res., 2018, 21(1), 81-85.
[22]
Kakpo, A.B.; Yayi, E.; Lenta, B.N.; Assogba, F.M.; Toclo, P.M.; Boyom, F.F.; Baba-Moussa, L.; Gbenou, J. Phytochemistry and anti-bacterial activity of thirteen plants used in traditional medicine to treat typhoid fever in Benin. Int. J. Innov. Appl. Stud., 2019, 25(3), 1034-1047.
[23]
Houngbeme, A.G.; Gandonou, C.; Yehouenou, B.; Kpoviessi, S.D.S.; Sohounhloue, D.; Moudachirou, M.; Gbaguidi, F.A. Phytochemical analysis, toxicity and antibacterial activity of Benin medicinal plants extracts used in the treatment of sexually transmitted infections associated with HIV/AIDS. Int. J. Pharm. Sci. Res., 2014, 5(5), 1739-1745.
[24]
Attah, C.O.; Sunday, I.; Lamido, D.M.; Salisu, A.R.; Muhammad, A.I.; Yunusa, I. Preliminary Phytochemical and Antibacterial Screening of Acanthospermum hispidium. Int. J. Res. Appl. Nat. Sci., 2016, 2(1), 101-112.
[25]
Okoro, I. O.; Inegbedion, A. O.; Okoro, E. O. Phytochemical screening and antibacterial activity of diferent solvent extracts of Acanthospermum hispidum DC. Aerial Parts. Nigerian Annal. Nat. Sci., 2017, 16(1), 043-047.
[26]
Palozi, R.A.C.; Schaedler, M.I.; Tirloni, C.A.S.; Silva, A.O.; Lívero, F.A.d.R.; Souza, R.I.C.; dos Santos, A.C.; Prando, T.B.L.; de Souza, L.M.; Gasparotto, A. Junior Roles of nitric oxide and prostaglandins in the sustained antihypertensive effects of Acanthospermum hispidum DC. on ovariectomized rats with renovascular hypertension. Evid. Based Complement. Alternat. Med., 2017, 2017, Article ID 2492483.
[27]
Yang, W.; Chen, X.; Li, Y.; Guo, S.; Wang, Z.; Yu, X. Advances in pharmacological activities of terpenoids. 2020, 15(3), 1934578X20903555.
[http://dx.doi.org/10.1177/1934578X20903555]
[28]
N’do, J.Y.; Hilou, A.; Ouedraogo, N.; Sombie, E.N.; Traore, T.K. Phytochemistry, antioxidant, and hepatoprotective potential of Acanthospermum hispidum DC Extracts against Diethylnitrosamine-Induced Hepatotoxicity in Rats. Medicines (Basel), 2018, 5(2), E42.
[http://dx.doi.org/10.3390/medicines5020042] [PMID: 29735893]
[29]
N’Do, J.Y-p.; Hilou, A.; Pare, D.; Sombie, E.N.; Traore, T.K.; Tibiri, A. In vivo Hepatoprotective Potential and Antioxidant Properties of Fractions Derived from the Ethanolic Extract of Acanthospermum hispidum DC. J. Global Biosci., 2019, 8(3), 6100-6119.
[30]
Elufioye, T.O.; Machie, S.C. Anticholinesterase activities of methanol extract and partitioned fractions of Acanthospermum hispidum DC. Niger. J. Nat. Prod. Med., 2016, 20, 67-72.
[http://dx.doi.org/10.4314/njnpm.v20i0.12]
[31]
Himaja, N. Comparitive study of hepatoprotective activity of Acanthospermum hispidum plant extract and herbal niosomal suspension against anti-tubercular drug induced hepatotoxicity in rats. Asian J. Pharm. Clin. Res., 2015, 8(5), 301-304.
[32]
N’do, J.Y-P.; Hilou, A.; Pare, D.; Sombie, E.N.; Traore, T.K.; Ouedraogo, N.; Tibiri, A.; Lagnika, L. Protective effect of Acanthospermum hispidum DC (Asteraceae) extracts against diethylnitrosamine induced hepatocellular damage. J. Complement. Alternat. Med. Res., 2018, 6(4), 1-13.
[http://dx.doi.org/10.9734/JOCAMR/2018/44474]
[33]
N’do, J.Y-P.; Hilou, A.; Pare, D.; Sombie, E.N.; Guenne, S.; Tibiri, A. In vivo Antifibrotic Potential of Extracts of Acanthospermum hispidum DC. Evaluated in wistar rats using diethylnitrosamine. Int. J. Trop. Dis. Health, 2019, 36(1), 1-9.
[34]
Tirloni, C.A.S.; Lívero, F.A.D.R.; Palozi, R.A.C.; Silveira, R.C.A.; Vasconcelos, P.C.P.; Souza, R.I.C.; Dos Santos, A.C.; de Almeida, V.P.; Manfron Budel, J.; de Souza, L.M.; Gasparotto, Junior, A. Ethnopharmacological investigations of the cardio-renal properties of a native species from the region of Pantanal, state of Mato Grosso do Sul, Brazil. J. Ethnopharmacol., 2017, 206, 125-134.
[http://dx.doi.org/10.1016/j.jep.2017.05.027] [PMID: 28549859]
[35]
Gomathi, V.; Palanisamy, P.; Jaykar, B. Preliminary phytochemical and in-vitro antioxidant activity of the whole plant of Acanthospermum hispidum DC. Int. J. Med. Pharm., 2013, 1(1), 22-32.
[36]
N’do, J.Y-p.; Hilou, A.; Pare, D.; Guenne, S.; Tibiri, A. Ethnobotany and pharmacognosic characterization of Acanthospermum hispidum (Asteraceae), A medicinal plant widely used in traditional medicine in the central west region (Burkina Faso). Int. J. Curr. Microbiol. Appl. Sci., 2019, 8(9), 97-108.
[http://dx.doi.org/10.20546/ijcmas.2019.809.014]
[37]
Shahidi, F.; Zhong, Y. Measurement of antioxidant activity. J. Funct. Foods, 2015, 18, 757-781.
[http://dx.doi.org/10.1016/j.jff.2015.01.047]
[38]
Koukouikila-Koussounda, F.; Abena, A.A.; Nzoungani, A.; Mombouli, J.V.; Ouamba, J.M.; Kun, J.; Ntoumi, F. In vitro evaluation of antiplasmodial activity of extracts of Acanthospermum hispidum DC (Asteraceae) and Ficus thonningii Blume (Moraceae), two plants used in traditional medicine in the Republic of Congo. Afr. J. Tradit. Complement. Altern. Med., 2012, 10(2), 270-276.
[PMID: 24146450]
[39]
Ogbole, O.O.; Segun, P.A.; Adeniji, A.J. In vitro cytotoxic activity of medicinal plants from Nigeria ethnomedicine on Rhabdomyosarcoma cancer cell line and HPLC analysis of active extracts. BMC Complement. Altern. Med., 2017, 17(1), 494.
[http://dx.doi.org/10.1186/s12906-017-2005-8] [PMID: 29166892]
[40]
Deepa, N.; Rajendran, N. Anti-tumor activity of Acanthospermum hispidum DC on dalton ascites lymphoma in mice. Nat. Prod. Sci., 2007, 13(3), 234-240.
[41]
Cartagena, E.; Alva, M.; Montanaro, S.; Bardón, A. Natural sesquiterpene lactones enhance oxacillin and gentamicin effectiveness against pathogenic bacteria without antibacterial effects on beneficial lactobacilli. Phytother. Res., 2015, 29(5), 695-700.
[http://dx.doi.org/10.1002/ptr.5301] [PMID: 25641272]
[42]
Houngbèmè, A. G.; Ganfon, H. M. Y.; Medegan, S.; Yèhouénou, B.; Bambola, B.; Gandonou, C.; Gbaguidi, F. A. Antimicrobial activity of compounds from Acanthospermum hispidum DC and Caesalpinia bonduc (L.) ROXB: Beninese plants used by healers against HIV-associated microbial infections. J. Appl. Pharmaceut. Sci., 2015, 5(08), 073-081.
[43]
Arena, M.E.; Cartagena, E.; Gobbato, N.; Baigori, M.; Valdez, J.C.; Bardon, A. In vivo and in vitro antibacterial activity of acanthospermal B, a sesquiterpene lactone isolated from Acanthospermum hispidum. Phytother. Res., 2011, 25(4), 597-602.
[http://dx.doi.org/10.1002/ptr.3300] [PMID: 20931621]
[44]
Fleischer, T.C.; Ameade, E.P.; Sawer, I.K. Antimicrobial activity of the leaves and flowering tops of Acanthospermum hispidum. Fitoterapia, 2003, 74(1-2), 130-132.
[http://dx.doi.org/10.1016/S0367-326X(02)00290-3] [PMID: 12628407]
[45]
Edewor, T.I.; Olajire, A.A. Two Flavones from Acanthospermum hispidum DC and their antibacterial activity. Int. J. Org. Chem. (Irvine), 2011, 1(03), 132.
[http://dx.doi.org/10.4236/ijoc.2011.13020]
[46]
Portillo, A.; Vila, R.; Freixa, B.; Adzet, T.; Cañigueral, S. Antifungal activity of Paraguayan plants used in traditional medicine. J. Ethnopharmacol., 2001, 76(1), 93-98.
[http://dx.doi.org/10.1016/S0378-8741(01)00214-8] [PMID: 11378288]
[47]
Ohashi, M.; Amoa-Bosompem, M.; Kwofie, K.D.; Agyapong, J.; Adegle, R.; Sakyiamah, M.M.; Ayertey, F.; Owusu, K.B.; Tuffour, I.; Atchoglo, P.; Tung, N.H.; Uto, T.; Aboagye, F.; Appiah, A.A.; Appiah-Opong, R.; Nyarko, A.K.; Anyan, W.K.; Ayi, I.; Boakye, D.A.; Koram, K.A.; Edoh, D.; Yamaoka, S.; Shoyama, Y.; Ohta, N. in vitro antiprotozoan activity and mechanisms of action of selected Ghanaian medicinal plants against Trypanosoma, Leishmania, and Plasmodium parasites. Phytother. Res., 2018, 32(8), 1617-1630.
[http://dx.doi.org/10.1002/ptr.6093] [PMID: 29733118]
[48]
Azeez, T.O.; Banigo, A.T. Phytochemical analysis of aqueous methanolic extract of Acanthospermum hispidium and its effect on biochemical and hematological indices in Plasmodium falciparum infected rats. Afr. J. Biomed. Res., 2018, 21(2), 183-192.
[49]
Ganfon, H.; Bero, J.; Tchinda, A.T.; Gbaguidi, F.; Gbenou, J.; Moudachirou, M.; Frédérich, M.; Quetin-Leclercq, J. Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C. J. Ethnopharmacol., 2012, 141(1), 411-417.
[http://dx.doi.org/10.1016/j.jep.2012.03.002] [PMID: 22440261]
[50]
Bero, J.; Hannaert, V.; Chataigné, G.; Hérent, M-F.; Quetin-Leclercq, J. In vitro antitrypanosomal and antileishmanial activity of plants used in Benin in traditional medicine and bio-guided fractionation of the most active extract. J. Ethnopharmacol., 2011, 137(2), 998-1002.
[http://dx.doi.org/10.1016/j.jep.2011.07.022] [PMID: 21782916]
[51]
Sanon, S.; Azas, N.; Gasquet, M.; Ollivier, E.; Mahiou, V.; Barro, N.; Cuzin-Ouattara, N.; Traore, A.S.; Esposito, F.; Balansard, G.; Timon-David, P. Antiplasmodial activity of alkaloid extracts from Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC), two plants used in traditional medicine in Burkina Faso. Parasitol. Res., 2003, 90(4), 314-317.
[http://dx.doi.org/10.1007/s00436-003-0859-9] [PMID: 12684889]
[52]
Sanon, S.; Ollivier, E.; Azas, N.; Mahiou, V.; Gasquet, M.; Ouattara, C.T.; Nebie, I.; Traore, A.S.; Esposito, F.; Balansard, G.; Timon-David, P.; Fumoux, F. Ethnobotanical survey and in vitro antiplasmodial activity of plants used in traditional medicine in Burkina Faso. J. Ethnopharmacol., 2003, 86(2-3), 143-147.
[http://dx.doi.org/10.1016/S0378-8741(02)00381-1] [PMID: 12738078]
[53]
Vivekanandhan, P.; Senthil-Nathan, S.; Shivakumar, M.S. Larvicidal, pupicidal and adult smoke toxic effects of Acanthospermum hispidum (DC) leaf crude extracts against mosquito vectors. Physiol. Mol. Plant Pathol., 2018, 101, 156-162.
[http://dx.doi.org/10.1016/j.pmpp.2017.05.005]
[54]
Olawumi, O.; Ibrahim, O.; Christianah, F. Tetrahydroanthracene Derivative: Anti-microbial Isolate from Acanthospermum hispidum DC. Int. J. Adv. Chem., 2014, 2(2), 182-184.
[http://dx.doi.org/10.14419/ijac.v2i2.3519]
[55]
Ogbole, O.O.; Aliu, L.O.; Abiodun, O.O.; Ajaiyeoba, E.O. Alphaamylase inhibition and brine shrimp lethality activities of nine medicinal plant extracts from south-west nigerian ethnomedicine. J. Herbs Spices Med. Plants, 2016, 22(4), 319-326.
[http://dx.doi.org/10.1080/10496475.2016.1214941]
[56]
Yahaya, T.A.; Sadiq, A.; Ifeoluwa, A.O.; Ibekwe, N.N.; Samuel, O.E.; Adeola, S.O. Behavioural effect of standardized aqueous whole plant extract of Acanthospermum hispidum: Ethnopharmacological justification for its use in folkloric management of malaria. Pharmacologyonline, 2013, 3, 45-55.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy