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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Research Article

Fe3O4@SiO2@CeO2 as a Potential Nanomagnetic Carrier for Oral Delivery System and Release of Celecoxib

Author(s): Shabnam Ahmadvand, Maryam Kargar Razi*, Babak Sadeghi and Seyedeh Sara Mirfazli

Volume 25, Issue 11, 2022

Published on: 05 January, 2022

Page: [1973 - 1984] Pages: 12

DOI: 10.2174/1386207324666210910160716

Price: $65

Abstract

Aims and Objective: In this study, an attempt was made to synthesize, characterize, and develop many applications of functionalized rare metal oxide nanoparticles. Herein, a new strategy for drug delivery is developed to functionalize magnetite nanoparticles to improve their performances in the delivery of celecoxib.

Materials and Methods: Magnetite Fe3O4@SiO2 nanoparticles are synthesized by the sol-gel method. The surface of the hydroxyl groups was extended by treating with cerium nitrate salt; finally, sodium hydroxide was anchored to the surface hydroxyl groups to produce cerium oxidefunctionalized Fe3O4@SiO2@CeO2 magnetic nanoparticles (FSC). The synthesized sample was characterized by FT-IR, FESEM, VSM, TGA, and XRD. Afterward, the functionalized nanoparticles were examined in the delivery of celecoxib as an active drug model involving cerium oxide and hydroxyl functional groups.

Results: For this purpose, the amount of loading/release of the drug was investigated in different amounts of nanocomposite and pH values.

Conclusion: The results of the present investigation indicate that the formulations (mFSC=5 mg, pH=3.3) can be considered as best among various formulations with respect to particle size, entrapment efficiency, and in-vitro successful drug release.

Keywords: Celecoxib, drug delivery, magnetite, nanocomposite, XRD, SEM.

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