Review of the Phytochemistry and Biological Activity of Cissus incisa Leaves

Title:Review of the Phytochemistry and Biological Activity of Cissus incisa Leaves

Volume: 21 Issue: 26

Author(s): Deyani Nocedo-Mena*, Adrián Alejandro Galván-Rodrigo, Colin W. Wright and Pierluigi Caboni*

Affiliation:

• Faculty of Physic-Mathematical Sciences, Autonomous University of Nuevo León, 66451, San Nicolss de los Garza, Nuevo Leon,Mexico

• Dipartamento Scienze della vita e dell’ambiente, Universita degli Studi di Cagliari, Cittadella Universitaria, Monserrato, C.P. 09042, Cagliari,Italy

Keywords: Cissus incisa, Vitaceae, Antimicrobial, Cytotoxic, Modeling, Molecular docking, Biophysical assay.

Abstract:

Background: Cissus incisa is a Vitaceae with a pantropical distribution. In northern Mexico, its leaves have traditionally been used to treat skin infections, abscesses and tumors. Despite its medicinal uses, few studies have been reported.

Objective: The objective of this study is to summarize the phytochemical and biological studies carried out so far on the leaves of C. incisa, since this part of the plant is the one frequently used, and awaken scientific interest towards the plant.

Methods: Since C. incisa was an undocumented species, most of the information comes from reports of our research group. Databases, books, and websites were also consulted. The information collected was organized and presented in a synthesized way. Plant name was checked with the database “The Plant List”.

Results: 171, 260, and 114 metabolites were identified by UHPLC-QFTOF-MS in the hexane, chloroform/ methanol, and aqueous extracts, respectively. Fatty acyls, sphingolipids, sterols, glycerolipids, prenol lipids, and terpenes are common metabolites found in these extracts. 2-(2´-hydroxydecanoyl amino)-1,3,4-hexadecanotriol-8-ene, 2,3-dihydroxypropyl tetracosanoate, β-sitosterol, β-sitosterol-D-glucopyranoside, α-amyrin-3-O-β-D-glucopyranoside were also isolated and characterized. Extracts, phytocompounds and semi-synthetic derivatives showed antimicrobial activity against multi-drug resistant bacteria and various cancer cell lines. Results from Perturbation- Theory-Machine Learning-Information-Fusion model (PTMLIF), molecular docking, and vesicular contents assay identified potential targets on the cell membrane, suggesting an antibacterial mechanism of action for ceramides from C. incisa leaves.

Conclusion: This review reports the efforts of the scientific community in authenticating species used in traditional medicine. Moreover, it gives a compendium of phytochemistry and the biological activities of the components from C. incisa leaves.

Cite this article as:

Nocedo-Mena Deyani *, Galván-Rodrigo Alejandro Adrián , Wright W. Colin and Caboni Pierluigi *, Review of the Phytochemistry and Biological Activity of Cissus incisa Leaves, Current Topics in Medicinal Chemistry 2021; 21 (26) . https://dx.doi.org/10.2174/1568026621666210909163612