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当代肿瘤药物靶点

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

糖尿病和乳腺癌之间的分子联系:以肠促肠素为基础的治疗乳腺癌的治疗潜力

卷 21, 期 10, 2021

发表于: 31 August, 2021

页: [829 - 848] 页: 20

弟呕挨: 10.2174/1568009621666210901101851

价格: $65

摘要

女性乳腺癌最近超过了肺癌,成为世界上最常见的癌症。根据世卫组织最近的数据,在估计230万新发癌症病例中,每8个确诊癌症病例中就有一个是乳腺癌。乳腺癌是妇女中最常见的癌症类型,导致癌症相关死亡率最高。据估计,2020年有685000名妇女死于这种疾病。乳腺癌具有不同程度的分子异质性;因此,它们被分为不同的临床分子亚型。最近的报告表明,2型糖尿病(世界上常见的慢性疾病之一)与不同癌症的高发病率、加速进展和侵袭性有关;尤其是乳腺癌。乳腺癌在本质上是激素依赖性的,与新陈代谢有相互作用。许多抗糖尿病疗法对包括乳腺癌在内的各种癌症都有有益的效果。然而,关于肠促胰岛素抗糖尿病治疗在整个癌症尤其是乳腺癌中的作用的报道很少。本综述阐明了肠促胰岛素治疗乳腺癌的潜力,并探讨了可能的潜在机制。此外,我们还讨论了乳腺癌的亚型以及糖尿病和乳腺癌之间复杂的关系。

关键词: 糖尿病,乳腺癌,利拉鲁肽,exendin-4,西格列汀,DPP-IV。

图形摘要

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