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Mini-Reviews in Medicinal Chemistry

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ISSN (Online): 1875-5607

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Review Article

Carbohydrazide Analogues: A Review of Synthesis and Biological Activities

Author(s): Ebuka Leonard Onyeyilim*, Mercy Amarachi Ezeokonkwo, David Izuchukwu Ugwu, Chiamaka Peace Uzoewulu , Florence Uchenna Eze, Vivian Ifeoma Okonkwo, Cosmas Chinweike Eze and James Anayochukwu Ezugwu

Volume 22, Issue 4, 2022

Published on: 31 August, 2021

Page: [661 - 682] Pages: 22

DOI: 10.2174/1389557521666210831154935

Price: $65

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Abstract

Carbohydrazides and their Schiff bases are important classes of heterocycles that are not only employed in the area of organic chemistry but also have tremendous applications in physical and inorganic chemistry. A series of potentially bioactive compounds containing carbohydrazide functionality and their hydrazone derivatives have been synthesized and screened for antibacterial, anticancer, antifungal and anti-inflammatory, etc. This brief review discloses some synthetic routes to so many reported carbohydrazides, their Schiff bases, their biological activities, and their structure-activity relationship.

Keywords: Carbohydrazide, schiff bases, hydrazone, hydrazinolysis, biological activities, structure-activity relationship.

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