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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

在癌症中靶向 Y-Box 结合蛋白 1 的潜在治疗策略

卷 21, 期 11, 2021

发表于: 31 August, 2021

页: [897 - 906] 页: 10

弟呕挨: 10.2174/1568009621666210831125001

价格: $65

摘要

作为进化中最保守的蛋白质之一，Y-box结合蛋白1（YB-1）长期以来一直被认为是潜在的癌症靶点。 YB-1通常在正常细胞中表达较差，发挥细胞生理功能，如DNA修复、pre-mRNA剪接和mRNA稳定。 在癌细胞中，YB-1的表达上调并经历核转位，并有助于肿瘤发生、血管生成、肿瘤增殖、侵袭、迁移和化疗耐药。 在过去的几十年中，已经开发出多种药理学工具，如 siRNA、shRNA、microRNA、环状 RNA、lncRNA 和各种化合物，以靶向 YB-1 进行癌症治疗。 在这篇综述中，我们详细描述了 YB-1 的生理特性，突出了 YB-1 在肿瘤中的作用，并总结了目前靶向 YB-1 在癌症中的治疗方法。

关键词: Y-box 结合蛋白 1、癌症、核易位模型、siRNA、shRNA、microRNA、环状 RNA、lncRNA。

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图形摘要

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