Multivesicular Liposome: A Lipid-based Drug Delivery System for Efficient Drug Delivery

Title:Multivesicular Liposome: A Lipid-based Drug Delivery System for Efficient Drug Delivery

Volume: 27 Issue: 43

Author(s): Bapi Gorain, Bandar E. Al-Dhubiab, Anroop Nair, Prashant Kesharwani, Manisha Pandey and Hira Choudhury*

Affiliation:

• Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Kuala Lumpur,Malaysia

Keywords: Multivesicular vesicles, liposomes, sustained and controlled release, prolonged circulation, high encapsulation, dosing frequencies.

Abstract: The advancement of delivery tools for therapeutic agents has brought several novel formulations with increased drug loading, sustained release, targeted delivery, and prolonged efficacy. Amongst the several novel delivery approaches, multivesicular liposome has gained potential interest because this delivery system possesses the above advantages. In addition, this multivesicular liposomal delivery prevents degradation of the entrapped drug within the physiological environment while administered. The special structure of the vesicles allowed successful entrapment of hydrophobic and hydrophilic therapeutic agents, including proteins and peptides. Furthermore, this novel formulation could maintain the desired drug concentration in the plasma for a prolonged period, which helps to reduce the dosing frequencies, improve bioavailability, and safety. This tool could also provide stability of the formulation, and finally gaining patient compliance. Several multivesicular liposomes received approval for clinical research, while others are at different stages of laboratory research. In this review, we have focused on the preparation of multivesicular liposomes along with their application in different ailments for the improvement of the performance of the entrapped drug. Moreover, the challenges of delivering multivesicular vesicles have also been emphasized. Overall, it could be inferred that multivesicular liposomal delivery is a platform of advanced drug delivery with improved efficacy and safety.

Cite this article as:

Gorain Bapi , Al-Dhubiab E. Bandar , Nair Anroop , Kesharwani Prashant , Pandey Manisha and Choudhury Hira *, Multivesicular Liposome: A Lipid-based Drug Delivery System for Efficient Drug Delivery, Current Pharmaceutical Design 2021; 27 (43) . https://dx.doi.org/10.2174/1381612827666210830095941