Abstract
Four different methods were used to measure the “in vitro” antioxidant capacity of three cobalt complexes recently proposed as anticancer active principles: a new biosensor method and a new pulse voltammetric, or pulse polarographic method, together with two other methods - one fluorimetric and the other spectrophotometric. Results obtained using the different methods are discussed and compared with the anti-metastatic effect recently measured “in vivo” by Russian authors. The good correlation found between anti-tumoral and anti-metastatic activity ranking and in vitro antioxidant activity found by the new voltammetric method suggests interesting hypotheses based on the anti-tumoral effect of these complexes.
Keywords: superoxide dismutase, ORAC Spectrofluorimetric Method, Differential Pulse Voltammetry, pH value, antioxidant
Current Pharmaceutical Analysis
Title: In Vitro Antioxidant Capacity vs In Vivo Antimetastatic Effect of Anticancer Cobalt Complexes
Volume: 4 Issue: 2
Author(s): Luigi Campanella, Gabriele Favero, Sergey P. Osinsky, Andrej L. Sigan and Mauro Tomassetti
Affiliation:
Keywords: superoxide dismutase, ORAC Spectrofluorimetric Method, Differential Pulse Voltammetry, pH value, antioxidant
Abstract: Four different methods were used to measure the “in vitro” antioxidant capacity of three cobalt complexes recently proposed as anticancer active principles: a new biosensor method and a new pulse voltammetric, or pulse polarographic method, together with two other methods - one fluorimetric and the other spectrophotometric. Results obtained using the different methods are discussed and compared with the anti-metastatic effect recently measured “in vivo” by Russian authors. The good correlation found between anti-tumoral and anti-metastatic activity ranking and in vitro antioxidant activity found by the new voltammetric method suggests interesting hypotheses based on the anti-tumoral effect of these complexes.
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Cite this article as:
Campanella Luigi, Favero Gabriele, Osinsky P. Sergey, Sigan L. Andrej and Tomassetti Mauro, In Vitro Antioxidant Capacity vs In Vivo Antimetastatic Effect of Anticancer Cobalt Complexes, Current Pharmaceutical Analysis 2008; 4 (2) . https://dx.doi.org/10.2174/157341208784246279
DOI https://dx.doi.org/10.2174/157341208784246279 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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