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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

外周血表观遗传加速老化并不能预测痴呆风险

卷 18, 期 5, 2021

发表于: 23 August, 2021

页: [443 - 451] 页: 9

弟呕挨: 10.2174/1567205018666210823100721

价格: $65

摘要

背景：有强有力的证据表明，表观遗传年龄加速与晚年疾病和全因死亡率的风险增加有关。然而，目前有限的证据表明表观遗传年龄的增加与痴呆风险有关。 目的：本研究旨在阐明加速衰老的表观遗传生物标志物是否可以预测痴呆风险，这是一个重要的考虑因素，因为衰老是该疾病的最大风险因素。 方法：从 ASPirin in Reducing Events in the Elderly 研究的 160 名参与者提供的外周血样本中测量 DNA 甲基化，包括 73 名症状前痴呆病例和 87 名年龄、性别、吸烟和教育状况匹配的对照。使用 Horvath、Hannum、GrimAge 和 PhenoAge DNA 甲基化时钟计算表观遗传年龄，并确定年龄加速（实足年龄和表观遗传年龄之间的差异）。 结果：痴呆病例和对照组之间的年龄加速没有差异。在男性中，与对照相比，在症状前痴呆病例中，只有 Hannum 的内在表观遗传年龄加速增加（Δ +1.8 岁，p = 0.03）。 结论：这些发现没有提供强有力的证据表明外周血中测量的表观遗传老化可以预测痴呆风险。

关键词: 加速衰老、痴呆、DNA 甲基化、表观遗传时钟、grimage、hannum、horvath、phenoAge。

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