Risk Factors for Alzheimer’s Disease: An Epidemiological Study

doi:10.2174/1567205018666210820124135

摘要

简介：痴呆症已成为捷克共和国和全世界的主要公共卫生挑战。最常见的痴呆症是阿尔茨海默病 (AD)。目标：我们在 2012-2015 年和 2016-2019 年连续开展了两个流行病学项目。他们的目的是通过比较 AD 患者和对照组中选定的潜在遗传、血管和社会心理风险因素对 AD 发展的影响。方法：进行流行病学病例对照研究。总共分析了 2106 名参与者（1096 名病例，1010 名对照）的数据。结果：患有AD的女性是男性的三倍。与对照组不同，病例比例最高的是那些接受过小学教育的病例。与对照组相比，病例中的体力劳动者在统计学上显着更多。在选定的血管危险因素中，发现冠心病在病例中的发生率显着高于对照组。高血压和糖尿病的发病在对照组中比在病例中早。至于爱好和兴趣，两组之间在体育活动、阅读和解决填字游戏方面存在统计学上的显着差异，这些活动在对照组中更为常见。结论：慢性神经退行性疾病，特别是 AD 的患病率目前正在增加。鉴于人口老龄化，这些疾病的流行率可能会上升。需要研究、分析和确认 AD 的潜在风险；因此，详细了解 AD 的风险和早期发现病理可能非常有利于预防和早期治疗这种情况。

关键词: 痴呆症、阿尔茨海默病、流行病学、风险因素、神经退行性疾病。

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[1] 
World Population Clock at the U.S. Census Bureau Available from: www.worldometers.info  cited 2019 December 12.
[2] 
Zvěřová M. Novinky v gerontopsychiatrii. Psychiatrpraxi  2019; 20(3): 108.: 110.Available from: https://www.psychiatriepropraxi.cz/artkey/psy-201903-0002_novinky_v_gerontopsychiatrii.php
[3] 
 Zpráva o stavu demence Česká alzheimerovská společnost 2015.Available from: http://www.alzheimer.cz/res/archive/004/000480. pdf?seek=1492589048
[4] 
Alzheimer´s disease International. World Alzheimer Report 2015.Available from: http://www.alz.co.uk/sites/default/files/pdfs/World-Report-2015
[5] 
Koncepce Alzheimer Ministerstvo zdravotnictví 2015.https://www. mzcr.cz/dokumenty/definitivni-navrh-koncepce-alzheimer_12998_ 3216_1.html
[6] 
Česká alzheimerovská společnost [Czech Alzheimer Society official
website] 2015.Available from: http://www.alzheimer.cz/alzheimerova-choroba/
[7] 
Höschl C, et al. Alzheimerova choroba.  Praha: Galén 1999; p. 96.
[8] 
Stern Y. Cognitive reserve in ageing and Alzheimer’s disease. Lancet Neurol  2012; 11(11): 1006-12.
[http://dx.doi.org/10.1016/S1474-4422(12)70191-6] [PMID: 23079557] 
[9] 
Launer LJ. The epidemiologic study of dementia: a life-long quest? Neurobiol Aging  2005; 26(3): 335-40.
[http://dx.doi.org/10.1016/j.neurobiolaging.2004.03.016] [PMID: 15639311] 
[10] 
Mortimer JA. Brain reserve and the clinical expression of Alzheimer’s disease. Geriatrics  1997; 52(Suppl. 2): S50-3.
[PMID: 9307589] 
[11] 
Norton MC, Østbye T, Smith KR, Munger RG, Tschanz JT. Early parental death and late-life dementia risk: findings from the Cache County Study. Age Ageing  2009; 38(3): 340-3.
[http://dx.doi.org/10.1093/ageing/afp023] [PMID: 19276094] 
[12] 
Mortimer JA. Chichester: Do Psychosocial Risk Factors Contribute to
Alzheimer’s Disease? In: Henderson AS, Henderson JH, Eds. In: Etiology
   of Dementia of Alzheimer’s type Dahlem Workshop, Report LS
   43.  John Wiley and Sons, USA 1988; pp. 39-52.
[13] 
Alzheimer´s disease International World Alzheimer Report
                    2014 2014.Available from: https://www.alz.co.uk/research/World AlzheimerReport2014.pdf
[14] 
Šerý O, Hlinecká L, Balcar VJ, Janout V, Povová J. Diabetes, hypertension and stroke - does Alzheimer protect you? Neuroendocrinol Lett  2014; 35(8): 691-6.
[PMID: 25702297] 
[15] 
Alonso Vilatela ME, López-López M, Yescas-Gómez P. Genetics of Alzheimer’s disease. Arch Med Res  2012; 43(8): 622-31.
[http://dx.doi.org/10.1016/j.arcmed.2012.10.017] [PMID:  23142261] 
[16] 
Mendez MF. Early-onset Alzheimer’s disease: nonamnestic subtypes and type 2 AD. Arch Med Res  2012; 43(8): 677-85.
[http://dx.doi.org/10.1016/j.arcmed.2012.11.009] [PMID: 23178565] 
[17] 
Jirák R, et al. Gerontopsychiatrie. Galén 2013.
[18] 
Bagyinszky E, Youn YC, An SS, Kim S. The genetics of Alzheimer’s disease. Clin Interv Aging  2014; 9: 535-51.
[http://dx.doi.org/10.2147/CIA.S51571] [PMID:  24729694] 
[19] 
Laws KR, Irvine K, Gale TM. Sex differences in Alzheimer’s disease. Curr Opin Psychiatry  2018; 31(2): 133-9.
[http://dx.doi.org/10.1097/YCO.0000000000000401] [PMID: 29324460] 
[20] 
Pike CJ. Sex and the development of Alzheimer’s disease. J Neurosci Res  2017; 95(1-2): 671-80.
[http://dx.doi.org/10.1002/jnr.23827] [PMID: 27870425] 
[21] 
Li R, Singh M. Sex differences in cognitive impairment and Alzheimer’s disease. Front Neuroendocrinol  2014; 35(3): 385-403.
[http://dx.doi.org/10.1016/j.yfrne.2014.01.002] [PMID: 24434111] 
[22] 
Hamson DK, Roes MM, Galea LA. Sex hormones and cognition: neuroendocrine influences on memory and learning. Compr Physiol  2016; 6(3): 1295-337.
[http://dx.doi.org/10.1002/cphy.c150031] [PMID: 27347894] 
[23] 
Janoutová J, Kovalová M, Ambroz P, et al. Alzheimerova choroba jako výzva pro veřejnézdravotnictví. Psychiatrprax  2019; 20(3): 139-41.Available from: https://www.psychiatriepropraxi.cz/artkey/psy-201903-0010.php
[24] 
Marioni RE, Proust-Lima C, Amieva H, et al. Social activity, cognitive decline and dementia risk: a 20-year prospective cohort study. BMC Public Health  2015; 15: 1089.
[http://dx.doi.org/10.1186/s12889-015-2426-6] [PMID: 26499254] 
[25
            ] 
Sommerlad A, Sabia S, Singh-Manoux A, Lewis G, Livingston G. Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study. PLoS Med  2019; 16(8)e1002862
[http://dx.doi.org/10.1371/journal.pmed.1002862] [PMID: 31374073] 
[26] 
Fratiglioni L, Wang H-X. Brain reserve hypothesis in dementia. J Alzheimers Dis  2007; 12(1): 11-22.
[http://dx.doi.org/10.3233/JAD-2007-12103] [PMID: 17851191] 
[27] 
Baumgart M, Snyder HM, Carrillo MC, Fazio S, Kim H, Johns H. Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective. Alzheimers Dement  2015; 11(6): 718-26.
[http://dx.doi.org/10.1016/j.jalz.2015.05.016] [PMID: 26045020] 
[28] 
Valenzuela MJ, Sachdev P. Brain reserve and dementia: a systematic review. Psychol Med  2006; 36(4): 441-54.
[http://dx.doi.org/10.1017/S0033291705006264] [PMID: 16207391] 
[29] 
Bennett DA, Arnold SE, Valenzuela MJ, Brayne C, Schneider JA. Cognitive and social lifestyle: links with neuropathology and cognition in late life. Acta Neuropathol  2014; 127(1): 137-50.
[http://dx.doi.org/10.1007/s00401-013-1226-2] [PMID: 24356982] 
[30] 
Dickstein DL, Walsh J, Brautigam H, Stockton SD Jr, Gandy S, Hof PR. Role of vascular risk factors and vascular dysfunction in Alzheimer’s disease. Mt Sinai J Med  2010; 77(1): 82-102.
[http://dx.doi.org/10.1002/msj.20155] [PMID: 20101718] 
[31] 
Panpalli Ates M, Karaman Y, Guntekin S, Ergun MA. Analysis of genetics and risk factors of Alzheimer’s Disease. Neuroscience  2016; 325: 124-31.
[http://dx.doi.org/10.1016/j.neuroscience.2016.03.051] [PMID: 27026590] 
[32] 
Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA  1997; 277(10): 813-7.
[http://dx.doi.org/10.1001/jama.1997.03540340047031] [PMID: 9052711] 
[33] 
Meng XF, Yu JT, Wang HF, et al. Midlife vascular risk factors and the risk of Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis  2014; 42(4): 1295-310.
[http://dx.doi.org/10.3233/JAD-140954] [PMID: 25024338] 
[34] 
Albai O, Frandes M, Timar R, Roman D, Timar B. Risk factors for developing dementia in type 2 diabetes mellitus patients with mild cognitive impairment. Neuropsychiatr Dis Treat  2019; 15: 167-75.
[http://dx.doi.org/10.2147/NDT.S189905] [PMID: 30655669] 
[35] 
Durazzo TC, Meyerhoff DJ, Yoder KK. Cigarette smoking is associated with cortical thinning in anterior frontal regions, insula and regions showing atrophy in early Alzheimer’s Disease. Drug Alcohol Depend  2018; 192: 277-84.
[http://dx.doi.org/10.1016/j.drugalcdep.2018.08.009] [PMID: 30300802] 
[36] 
Durazzo TC, Mattsson N, Weiner MW. Smoking and increased Alzheimer’s disease risk: a review of potential mechanisms. Alzheimers Dement  2014; 10(3)(Suppl.): S122-45.
[http://dx.doi.org/10.1016/j.jalz.2014.04.009] [PMID: 24924665] 
[37] 
Ho YS, Yang X, Yeung SC, et al. Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats. PLoS One  2012; 7(5)e36752
[http://dx.doi.org/10.1371/journal.pone.0036752] [PMID: 22606286] 
[38] 
Sonnen JA, Larson EB, Gray SL, et al. Free radical damage to cerebral cortex in Alzheimer’s disease, microvascular brain injury, and smoking. Ann Neurol  2009; 65(2): 226-9.
[http://dx.doi.org/10.1002/ana.21508] [PMID: 19259965] 
[39] 
Neafsey EJ, Collins MA. Moderate alcohol consumption and cognitive risk. Neuropsychiatr Dis Treat  2011; 7: 465-84.
[http://dx.doi.org/10.2147/NDT.S23159] [PMID: 21857787] 
[40] 
Sheardová K, Hudeček D. Prevence demence a životní styl. Neurol Praxi  2011; 12(6): 418-21. Available from: https://www. neurologiepropraxi.cz/artkey/neu-201106-0010_Prevence_demence_a_zivotni_styl.php
[41] 
Piazza-Gardner AK, Gaffud TJ, Barry AE. The impact of alcohol on Alzheimer’s disease: a systematic review. Aging Ment Health  2013; 17(2): 133-46.
[http://dx.doi.org/10.1080/13607863.2012.742488] [PMID: 23171229] 
[42] 
Heymann D, Stern Y, Cosentino S, Tatarina-Nulman O, Dorrejo JN, Gu Y. The Association Between Alcohol Use and the Progression of Alzheimer’s Disease. Curr Alzheimer Res  2016; 13(12): 1356-62.
[http://dx.doi.org/10.2174/1567205013666160603005035] [PMID: 27628432] 
[43] 
Okabayashi S, Kawamura T, Wakai K, et al. Lifestyle and psychosocial factors and a decline in competence in daily living among Japanese early elderly people: from an age-specified community-based cohort study (NISSIN project). Environ Health Prev Med  2019; 24(1): 28.
[http://dx.doi.org/10.1186/s12199-019-0787-7] [PMID: 31060492] 
[44] 
Crowe M, Andel R, Pedersen NL, Johansson B, Gatz M. Does participation in leisure activities lead to reduced risk of Alzheimer’s disease? A prospective study of Swedish twins. J Gerontol B Psychol Sci Soc Sci  2003; 58(5): 249-55.
[http://dx.doi.org/10.1093/geronb/58.5.P249] [PMID: 14507930] 
[45] 
Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol  2006; 5(1): 64-74.
[http://dx.doi.org/10.1016/S1474-4422(05)70284-2] [PMID: 16361024] 
[46] 
Stephen R, Hongisto K, Solomon A, Lönnroos E. Physical activity and Alzheimer’s disease: A systematic revieW. J Gerontol A Biol Sci Med Sci  2017; 72(6): 733-9.
[http://dx.doi.org/10.1093/gerona/glw251] [PMID: 28049634] 
[47] 
Hersi M, Irvine B, Gupta P, Gomes J, Birkett N, Krewski D. Risk factors associated with the onset and progression of Alzheimer’s disease: A systematic review of the evidence. Neurotoxicology  2017; 61: 143-87.
[http://dx.doi.org/10.1016/j.neuro.2017.03.006] [PMID: 28363508] 

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DOI https://dx.doi.org/10.2174/1567205018666210820124135	Print ISSN 1567-2050
Publisher Name Bentham Science Publisher	Online ISSN 1875-5828

当代阿耳茨海默病研究

阿尔茨海默病的危险因素：一项流行病学研究

摘要

当代阿耳茨海默病研究

阿尔茨海默病的危险因素：一项流行病学研究

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