Critical Review of Biotransformational Studies on Steroids by Using Culture of Cunninghamella blakesleeana

Title:Critical Review of Biotransformational Studies on Steroids by Using Culture of Cunninghamella blakesleeana

Volume: 18 Issue: 12

Author(s): Azizuddin*, M. Iqbal and Syed G. Musharraf

Affiliation:

• Department of Chemistry, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi 75300,Pakistan

Keywords: Biotransformation, steroids, androstane, pregnane, cholestane, Cunninghamella blakesleeana.

Abstract: For several decades, biotransformational studies on steroidal compounds have gained a lot of attention because it is an efficient approach for the structural modification of complicated natural or synthetic compounds with high regio-, chemo- and stereoselectivity at environmentally friendly conditions. This review summarizes the use of different strains of Cunninghamella blakesleeana for the biotransformation of sixteen steroids 1-16 into a variety of transformed products. The transformed products may be important as a drug or precursor for the production of important pharmaceuticals. The types of reactions performed by C. blakesleeana include hydroxylation, epoxidation, reduction, demethylation, oxidation, glycosidation, double bond formation, side-chain degradation, isomerisation and opening of an isoxazol ring, which would be difficult to produce by traditional synthesis.

Cite this article as:

Azizuddin *, Iqbal M. and Musharraf G. Syed , Critical Review of Biotransformational Studies on Steroids by Using Culture of Cunninghamella blakesleeana, Letters in Organic Chemistry 2021; 18 (12) . https://dx.doi.org/10.2174/1570178618666210820110400