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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

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ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

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Case Report

Concomitant use of Tyrosine-Kinase Inhibitor and Mepolizumab in Asthma Secondary to Chronic Myeloid Leukemia with Hypereosinophilia

Author(s): Antonio Gidaro*, Emanuele Salvi, Maria Cristina Carraro, Roberta Simona Rossi and Roberto Castelli

Volume 20, Issue 4, 2021

Published on: 20 August, 2021

Page: [389 - 393] Pages: 5

DOI: 10.2174/1871523020999210820091109

Price: $65

Abstract

Introduction: Asthma and hypereosinophilia have been treated with different therapeutics in the past. Some of them appear to be more effective in symptoms resolution and decreasing eosinophilic count.

Case Presentation: We report here an unusual case of asthma with hypereosinophilia secondary to Chronic Myeloid Leukemia (CML) with high prevalence of eosinophilic infiltrate, treated simultaneously with an anti-IL-5 antibody (Mepolizumab) and Tyrosine-kinase Inhibitors (TKI: Imatinib and Bosutinib) for three years. The patient showed a promising reduction of pulmonary exacerbations and good control of CML without developing side effects.

Conclusion: We hope that this finding could inspire further studies on the efficacy and safety of the concomitant use of anti-IL-5 and TKI.

Keywords: Asthma, chronic myeloid leukemia (CML), tyrosine kinase inhibitors (TKI), mepolizumab, hypereosinophilia (HE), eosinophilic count.

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Graphical Abstract

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