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Mini-Review Article

长链非编码 RNA HOTTIP 的分子调控作用：胃肠癌概述

卷 22, 期 6, 2022

发表于: 06 August, 2021

页: [478 - 490] 页: 13

弟呕挨: 10.2174/1566524021666210806162848

价格: $65

摘要

胃肠道 (GI) 癌症在全球范围内出现了数量惊人的新癌症病例，并且以预后不良为特征。较差的总生存期主要是由于发现较晚和治疗中出现的挑战，特别是化学抗性。因此，识别胃肠道癌症中的新分子靶点被高度视为主要焦点。最近，长链非编码 RNA (lncRNA) 被发现是对抗癌症的潜在新分子靶点，因为它们与癌变高度相关，对癌症进展有很大影响。在 lncRNA 中，HOTTIP 已证明在癌症进展中具有显着的致癌调节作用，特别是在 GI 癌症中，包括食道癌、胃癌、肝细胞癌、胰腺癌和结直肠癌。本综述旨在重点介绍 HOTTIP 在 GI 癌症进展和化学抗性中的调节作用，以及破译其对癌症表型和化学抗性影响的相关分子机制以及所涉及的关键分子。据报道，它调节 GI 癌症中各种基因和蛋白质的表达，这些基因和蛋白质影响细胞功能，包括增殖、粘附、迁移和侵袭、细胞凋亡、化学敏感性和肿瘤分化。此外，还发现与现有的诊断生物标志物相比，HOTTIP 具有更高的诊断价值。总体而言，HOTTIP 已成为胃肠道癌症治疗发展中的一种新的治疗靶点和潜在的诊断生物标志物。

关键词: 分子靶点、lncRNA、HOTTIP、胃肠癌、癌症治疗、药物发现。

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