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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Review Article

Cell-adhesion Molecules as Key Mechanisms of Tumor Invasion: The Case of Breast Cancer

Author(s): Carla Luís, Raquel Soares, Rúben Fernandes and Mónica Botelho*

Volume 23, Issue 2, 2023

Published on: 10 March, 2022

Page: [147 - 160] Pages: 14

DOI: 10.2174/1566524021666210806155231

Price: $65

Abstract

Cancer is a major health problem worldwide and the second leading cause of death following cardiovascular diseases. Breast cancer is the leading cause of mortality and morbidity among women and one of the most common malignant neoplasms prompt to metastatic disease.

In the present review, the mechanisms of the major cell adhesion molecules involved in tumor invasion are discussed, focusing on the case of breast cancer. A non-systematic updated revision of the literature was performed in order to assemble information regarding the expression of the adhesion cell molecules associated with metastasis.

Keywords: Breast cancer, metastasis, cell adhesion molecules, cadherins, selectins, integrins, igcam.

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