Abstract
Hydroxytyrosol is a phenol found predominantly in the olive tree (Olea europea). It shows a broad spectrum of beneficial effects such as cancer chemoprevention by inducing apoptosis, cardioprotection and anti-atherogenic activity, skin photoprotection and anti-inflammatory activity. These biological properties are based on scavenging of reactive oxygen species by hydroxytyrosol, being more active than antioxidant vitamins and synthetic antioxidants. Its biological activities and beneficial effects on human health has stimulated the development of new methods of extraction and purification from olive mill wastewater, from table olive processing, or from leaves. Different procedures for the chemical and enzymatic synthesis of hydroxytyrosol have been developed from tyrosol, from 3,4-dihydroxyphenylacetic acid and its methyl ester, and from oleuropein. Some hydroxytyrosol acyl derivatives have been prepared by chemical and chemoenzimatic methods in order to increase both stability and solubility in lipophilic preparations. Mechanistic experiments on hydroxytyrosol oxidation and isolation of species formed by oxidation are also reported.
Current Organic Chemistry
Title: Hydroxytyrosol and Derivatives: Isolation, Synthesis, and Biological Properties
Volume: 12 Issue: 6
Author(s): Jose G. Fernandez-Bolanos, Oscar Lopez, Juan Fernandez-Bolanos and Guillermo Rodriguez-Gutierrez
Affiliation:
Abstract: Hydroxytyrosol is a phenol found predominantly in the olive tree (Olea europea). It shows a broad spectrum of beneficial effects such as cancer chemoprevention by inducing apoptosis, cardioprotection and anti-atherogenic activity, skin photoprotection and anti-inflammatory activity. These biological properties are based on scavenging of reactive oxygen species by hydroxytyrosol, being more active than antioxidant vitamins and synthetic antioxidants. Its biological activities and beneficial effects on human health has stimulated the development of new methods of extraction and purification from olive mill wastewater, from table olive processing, or from leaves. Different procedures for the chemical and enzymatic synthesis of hydroxytyrosol have been developed from tyrosol, from 3,4-dihydroxyphenylacetic acid and its methyl ester, and from oleuropein. Some hydroxytyrosol acyl derivatives have been prepared by chemical and chemoenzimatic methods in order to increase both stability and solubility in lipophilic preparations. Mechanistic experiments on hydroxytyrosol oxidation and isolation of species formed by oxidation are also reported.
Export Options
About this article
Cite this article as:
Fernandez-Bolanos G. Jose, Lopez Oscar, Fernandez-Bolanos Juan and Rodriguez-Gutierrez Guillermo, Hydroxytyrosol and Derivatives: Isolation, Synthesis, and Biological Properties, Current Organic Chemistry 2008; 12 (6) . https://dx.doi.org/10.2174/138527208784083888
DOI https://dx.doi.org/10.2174/138527208784083888 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nutrapharmacology of Tocotrienols for Metabolic Syndrome
Current Pharmaceutical Design An Epigenetic Approach to Pancreatic Cancer Treatment: The Prospective Role of Histone Deacetylase Inhibitors
Current Cancer Drug Targets Myc - What We have Learned from Flies
Current Drug Targets Engineered Nanoparticles Against MDR in Cancer: The State of the Art and its Prospective
Current Pharmaceutical Design Cellular FLICE-Like Inhibitory Protein (C-FLIP): A Novel Target for Cancer Therapy
Current Cancer Drug Targets Role of Androgen Receptor in Prostate Cancer Cell Cycle Regulation: Interaction with Cell Cycle Regulatory Proteins and Enzymes of DNA Synthesis
Current Protein & Peptide Science Meta-heuristic Techniques to Train Artificial Neural Networks for Medical Image Classification: A Review
Recent Advances in Computer Science and Communications To Analyze the Amelioration of Phenobarbital Induced Oxidative Stress by Erucin, as Indicated by Biochemical and Histological Alterations
Anti-Cancer Agents in Medicinal Chemistry In Vitro Models of Human T Cell Development: Dishing Out Progenitor T Cells
Current Immunology Reviews (Discontinued) Oxidovanadium(IV) Complex Disrupts Mitochondrial Membrane Potential and Induces Apoptosis in Pancreatic Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Inhibition of Melanogenesis by Some Well-Known Polyphenolics: A Review
Current Pharmaceutical Biotechnology Stem Cells and Combinatorial Science
Combinatorial Chemistry & High Throughput Screening Induced pluripotent stem cell-derived mesenchymal stem cells: A leap toward personalized therapies.
Current Stem Cell Research & Therapy Molecular Dynamics in Esophageal Adenocarcinoma: Who’s in Control?
Current Cancer Drug Targets Novel HSP90 Inhibitor NVP-AUY922 Enhances the Anti-tumor Effect of Temsirolimus Against Oral Squamous Cell Carcinoma
Current Cancer Drug Targets The Role of the Healthy Dietary Intake in Women with Human Papilloma Virus
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Pharmacokinetics of Gefitinib: Roles of Drug Metabolizing Enzymes and Transporters
Current Drug Delivery The Anti-tumor Activity and Mechanisms of rLj-RGD3 on Human Laryngeal Squamous Carcinoma Hep2 Cells
Anti-Cancer Agents in Medicinal Chemistry Mechanisms of Apoptosis Induced by Anticancer Compounds in Melanoma Cells
Current Topics in Medicinal Chemistry Editorial (Hot Topic:Recent Advance in the Studies of Beta-glucans for Cancer Therapy)
Anti-Cancer Agents in Medicinal Chemistry