摘要
肿瘤微环境的复杂性和肿瘤的多样性严重影响了治疗效果,因此,为了提高疗效,临床研究的重点已逐渐从单一治疗转向联合治疗。多种单一疗法之间的协同增强相互作用主要促成了多模式合作治疗的诞生,其治疗的效果明显强于任何单一疗法。此外,对肿瘤位置的准确诊断对治疗也是至关重要的。铋基纳米材料(NMs)具有其独特的特性,包括低毒性、优良的光热转换效率以及高x射线计算机断层扫描和光声成像能力,具有巨大的性能,是很有前途的治疗平台。在这篇文章中,我们将简要介绍肿瘤微环境的主要特性及其对纳米医学作用机制的影响和目前铋的进展诊断和光热治疗使用铋联合疗法,这可能为您提供一种新的方法克服耐药性和缺氧。最后,本文讨论了这一有前景领域的进一步挑战和前景,并提出了铋纳米纳米的一些设计技巧,希望为研究人员提供一些灵感,为设计安全有效的癌症纳米治疗药物提供帮助。
关键词: 基于铋的NMs,光热治疗,治疗剂,癌症诊断和治疗,x射线计算机断层扫描成像,光声成像。
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