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Mini-Reviews in Medicinal Chemistry

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ISSN (Online): 1875-5607

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Review Article

Promising Enzymes for Inhibitors Development Against COVID-19

Author(s): Zhi-Gang Sun*, Feng-Ling Yu, Xiang-Ting Qiu, Shuang Li, Xue-Tang Li and Hai-Liang Zhu

Volume 22, Issue 3, 2022

Published on: 05 August, 2021

Page: [449 - 456] Pages: 8

DOI: 10.2174/1389557521666210805104250

Price: $65

Abstract

After the emergence of COVID-19 in 2019, it has now become a pandemic. COVID-19 has brought painful disasters to people all over the world. It not only threatens lives and health but also induces economic crises. At present, promising methods to eradicate COVID-19 mainly include drugs and vaccines. Enzyme inhibitors have always been a reliable strategy for the treatment of related diseases. Scientists worldwide have worked together to study COVID-19, obtained the structure of key SARS-CoV-2 associated enzymes, and reported the research of inhibitors of these enzymes. This article summarizes COVID-19-related enzyme inhibitors' recent development, mainly including 3CLpro, PLpro, TMPRSS2, and RdRp inhibitors, hoping to provide valuable weapons in the ensuing battle against COVID-19.

Keywords: COVID-19, DPP-4, SARS-CoV-2, inhibitors, 3CLpro, PLpro, TMPRSS2, RdRp.

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Graphical Abstract

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