Abstract
Adult stem cells like mammary and mesenchymal stem cells have received significant attention because these stem cells possess therapeutic potential in treating many animal diseases. These cells can be administered in an autologous or allogenic fashion, either freshly isolated from the donor tissue or previously cultured and expanded in vitro. The expansion of adult stem cells is a prerequisite before therapeutic application because sufficient numbers are required in dosage calculation. Stem cells directly and indirectly (by secreting various growth factors and angiogenic factors called secretome) act to repair and regenerate injured tissues. Recent studies on mammary stem cells showed in vivo and in vitro expansion ability by removing the blockage of asymmetrical cell division. Compounds like purine analogs (xanthosine, xanthine, and inosine) or hormones (progesterone and bST) help increase stem cell population by promoting cell division. Such methodology of enhancing stem cell number, either in vivo or in vitro, may help in preclinical studies for translational research like treating diseases such as mastitis. The application of mesenchymal stem cells has also been shown to benefit mammary gland health due to the ‘homing’ property of stem cells. In addition to that, the multiple positive effects of stem cell secretome are on mammary tissue; healing and killing bacteria is novel in the production of quality milk. This systematic review discusses some of the studies on stem cells that have been useful in increasing the stem cell population and increasing mammary stem/progenitor cells. Finally, we provide insights into how enhancing mammary stem cell population could potentially increase terminally differentiated cells, ultimately leading to more milk production.
Keywords: Bovine, gland health, stem cells, production potential, SACKs, xanthosine.
[1]
Choudhary RK, Li RW, Evock-Clover CM, Capuco AV. Comparison of the transcriptomes of long-term label retaining-cells and control cells microdissected from mammary epithelium: an initial study to characterize potential stem/progenitor cells. Front Oncol 2013; 3(21): 21.
[http://dx.doi.org/10.3389/fonc.2013.00021] [PMID: 23423481]
[http://dx.doi.org/10.3389/fonc.2013.00021] [PMID: 23423481]
[2]
Capuco AV, Ellis S. Bovine mammary progenitor cells: Current concepts and future directions. J Mammary Gland Biol Neoplasia 2005; 10(1): 5-15.
[http://dx.doi.org/10.1007/s10911-005-2536-3] [PMID: 15886882]
[http://dx.doi.org/10.1007/s10911-005-2536-3] [PMID: 15886882]
[3]
Capuco AV, Wood DL, Baldwin R, Mcleod K, Paape MJ. Mammary cell number, proliferation, and apoptosis during a bovine lactation: Relation to milk production and effect of bST. J Dairy Sci 2001; 84(10): 2177-87.
[http://dx.doi.org/10.3168/jds.S0022-0302(01)74664-4] [PMID: 11699449]
[http://dx.doi.org/10.3168/jds.S0022-0302(01)74664-4] [PMID: 11699449]
[4]
Herve L, Quesnel H, Lollivier V, Boutinaud M. Regulation of cell number in the mammary gland by controlling the exfoliation process in milk in ruminants. J Dairy Sci 2016; 99(1): 854-63.
[http://dx.doi.org/10.3168/jds.2015-9964] [PMID: 26433413]
[http://dx.doi.org/10.3168/jds.2015-9964] [PMID: 26433413]
[5]
Ben Chedly H, Boutinaud M, Bernier-Dodier P, Marnet PG, Lacasse P. Disruption of cell junctions induces apoptosis and reduces synthetic activity in lactating goat mammary gland. J Dairy Sci 2010; 93(7): 2938-51.
[http://dx.doi.org/10.3168/jds.2009-2678] [PMID: 20630211]
[http://dx.doi.org/10.3168/jds.2009-2678] [PMID: 20630211]
[6]
Ben Chedly H, Lacasse P, Marnet PG, Boutinaud M. The decrease in milk yield during once daily milking is due to regulation of synthetic activity rather than apoptosis of mammary epithelial cells in goats. Animal 2013; 7(1): 124-33.
[http://dx.doi.org/10.1017/S1751731112001176] [PMID: 23031579]
[http://dx.doi.org/10.1017/S1751731112001176] [PMID: 23031579]
[7]
Boutinaud M, Ben Chedly MH, Delamaire E, Guinard-Flament J. Milking and feed restriction regulate transcripts of mammary epithelial cells purified from milk. J Dairy Sci 2008; 91(3): 988-98.
[http://dx.doi.org/10.3168/jds.2007-0587] [PMID: 18292254]
[http://dx.doi.org/10.3168/jds.2007-0587] [PMID: 18292254]
[8]
Jacobs AAA, van Baal J, Smits MA, et al. Effects of feeding rapeseed oil, soybean oil, or linseed oil on stearoyl-CoA desaturase expression in the mammary gland of dairy cows. J Dairy Sci 2011; 94(2): 874-87.
[http://dx.doi.org/10.3168/jds.2010-3511] [PMID: 21257056]
[http://dx.doi.org/10.3168/jds.2010-3511] [PMID: 21257056]
[9]
Gudjonsson T, Adriance MC, Sternlicht MD, Petersen OW, Bissell MJ. Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia 2005; 10(3): 261-72.
[http://dx.doi.org/10.1007/s10911-005-9586-4] [PMID: 16807805]
[http://dx.doi.org/10.1007/s10911-005-9586-4] [PMID: 16807805]
[10]
Neville MC, McFadden TB, Forsyth I. Hormonal regulation of mammary differentiation and milk secretion. J Mammary Gland Biol Neoplasia 2002; 7(1): 49-66.
[http://dx.doi.org/10.1023/A:1015770423167] [PMID: 12160086]
[http://dx.doi.org/10.1023/A:1015770423167] [PMID: 12160086]
[11]
Kordon EC, Smith GH. An entire functional mammary gland may comprise the progeny from a single cell. Development 1998; 125(10): 1921-30.
[http://dx.doi.org/10.1242/dev.125.10.1921] [PMID: 9550724]
[http://dx.doi.org/10.1242/dev.125.10.1921] [PMID: 9550724]
[12]
Smith GH, Chepko G. Mammary epithelial stem cells. Microsc Res Tech 2001; 52(2): 190-203.
[http://dx.doi.org/10.1002/1097-0029(20010115)52:2<190::AID-JEMT1005>3.0.CO;2-O] [PMID: 11169867]
[http://dx.doi.org/10.1002/1097-0029(20010115)52:2<190::AID-JEMT1005>3.0.CO;2-O] [PMID: 11169867]
[13]
Shackleton M, Vaillant F, Simpson KJ, et al. Generation of a functional mammary gland from a single stem cell. Nature 2006; 439(7072): 84-8.
[http://dx.doi.org/10.1038/nature04372] [PMID: 16397499]
[http://dx.doi.org/10.1038/nature04372] [PMID: 16397499]
[14]
Rauner G, Barash I. Cell hierarchy and lineage commitment in the bovine mammary gland. PLoS One 2012; 7(1): e30113.
[http://dx.doi.org/10.1371/journal.pone.0030113] [PMID: 22253899]
[http://dx.doi.org/10.1371/journal.pone.0030113] [PMID: 22253899]
[15]
Crisan M, Yap S, Casteilla L, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008; 3(3): 301-13.
[http://dx.doi.org/10.1016/j.stem.2008.07.003] [PMID: 18786417]
[http://dx.doi.org/10.1016/j.stem.2008.07.003] [PMID: 18786417]
[16]
Voga M, Adamic N, Vengust M, Majdic G. Stem cells in veterinary medicine-current state and treatment options. Front Vet Sci 2020; 7: 278.
[http://dx.doi.org/10.3389/fvets.2020.00278]
[http://dx.doi.org/10.3389/fvets.2020.00278]
[17]
Marx C, Silveira MD, Beyer Nardi N. Adipose-derived stem cells in veterinary medicine: Characterization and therapeutic applications. Stem Cells Dev 2015; 24(7): 803-13.
[http://dx.doi.org/10.1089/scd.2014.0407] [PMID: 25556829]
[http://dx.doi.org/10.1089/scd.2014.0407] [PMID: 25556829]
[18]
Peralta OA, Carrasco C, Vieytes C, et al. Safety and efficacy of a mesenchymal stem cell intramammary therapy in dairy cows with experimentally induced Staphylococcus aureus clinical mastitis. Sci Rep 2020; 10(1): 2843.
[http://dx.doi.org/10.1038/s41598-020-59724-7] [PMID: 32071371]
[http://dx.doi.org/10.1038/s41598-020-59724-7] [PMID: 32071371]
[19]
Cahuascanco B, Bahamonde J, Huaman O, et al. Bovine fetal mesenchymal stem cells exert antiproliferative effect against mastitis causing pathogen Staphylococcus Aureus. Vet Res 2019; 50(1): 1-10.
[http://dx.doi.org/10.1186/s13567-019-0643-1]
[http://dx.doi.org/10.1186/s13567-019-0643-1]
[20]
Tao H, Han Z, Han ZC, Li Z. Proangiogenic features of mesenchymal stem cells and their therapeutic applications. Stem Cells Int 2016; 2016: 1314709.
[http://dx.doi.org/10.1155/2016/1314709]
[http://dx.doi.org/10.1155/2016/1314709]
[21]
Costa CRM, Feitosa MLT, Rocha AR, et al. Adipose stem cells in reparative goat mastitis mammary gland. PLoS One 2019; 14(10): e0223751.
[http://dx.doi.org/10.1371/journal.pone.0223751] [PMID: 31639137]
[http://dx.doi.org/10.1371/journal.pone.0223751] [PMID: 31639137]
[22]
Hill ABT, Bressan FF, Murphy BD, Garcia JM. Applications of mesenchymal stem cell technology in bovine species. Stem Cell Res Ther 2019; 10(1): 44.
[http://dx.doi.org/10.1186/s13287-019-1145-9] [PMID: 30678726]
[http://dx.doi.org/10.1186/s13287-019-1145-9] [PMID: 30678726]
[23]
Petrenko Y, Vackova I, Kekulova K, et al. A comparative analysis of multipotent mesenchymal stromal cells derived from different sources, with a focus on neuroregenerative potential. Sci Rep 2020; 10(1): 4290.
[http://dx.doi.org/10.1038/s41598-020-61167-z] [PMID: 32152403]
[http://dx.doi.org/10.1038/s41598-020-61167-z] [PMID: 32152403]
[24]
Song N, Scholtemeijer M, Shah K. Mesenchymal stem cell immunomodulation: Mechanisms and therapeutic potential. Trends Pharmacol Sci 2020; 41(9): 653-64.
[http://dx.doi.org/10.1016/j.tips.2020.06.009]
[http://dx.doi.org/10.1016/j.tips.2020.06.009]
[25]
Portela RF, Fadl-Alla BA, Pondenis HC, et al. Pro-tumorigenic effects of transforming growth factor beta 1 in canine osteosarcoma. J Vet Intern Med 2014; 28(3): 894-904.
[http://dx.doi.org/10.1111/jvim.12348] [PMID: 24684686]
[http://dx.doi.org/10.1111/jvim.12348] [PMID: 24684686]
[26]
Xu X, Zheng L, Yuan Q, et al. Transforming growth factor-β in stem cells and tissue homeostasis. Bone Res 2018; 6: 2.
[http://dx.doi.org/10.1038/s41413-017-0005-4]
[http://dx.doi.org/10.1038/s41413-017-0005-4]
[27]
Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 2013; 200(4): 373-83.
[http://dx.doi.org/10.1083/jcb.201211138] [PMID: 23420871]
[http://dx.doi.org/10.1083/jcb.201211138] [PMID: 23420871]
[28]
Park KS, Svennerholm K, Shelke GV, et al. Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10. Stem Cell Res Ther 2019; 10(1): 231.
[http://dx.doi.org/10.1186/s13287-019-1352-4] [PMID: 31370884]
[http://dx.doi.org/10.1186/s13287-019-1352-4] [PMID: 31370884]
[29]
Hyvärinen K, Holopainen M, Skirdenko V, et al. Mesenchymal stromal cells and their extracellular vesicles enhance the anti-inflammatory phenotype of regulatory macrophages by downregulating the production of interleukin (IL)-23 and IL-22. Front Immunol 2018; 9: 771.
[http://dx.doi.org/10.3389/fimmu.2018.00771] [PMID: 29706969]
[http://dx.doi.org/10.3389/fimmu.2018.00771] [PMID: 29706969]
[30]
Crain SK, Robinson SR, Thane KE, et al. acellular vesicles from Wharton’s jelly mesenchymal stem cells suppress CD4 expressing t cells through transforming growth factor beta and adenosine signaling in a Canine model. Stem Cells Dev 2019; 28(3): 212-26.
[http://dx.doi.org/10.1089/scd.2018.0097] [PMID: 30412034]
[http://dx.doi.org/10.1089/scd.2018.0097] [PMID: 30412034]
[31]
Zhao Q, Ren H, Han Z. Shanghai hengrun biomedical technology research institute. Mesenchymal stem cells: Immunomodulatory capability and clinical potential in immune diseases. J Cell Immunother 2016; 2(1): 3-20.
[http://dx.doi.org/10.1016/j.jocit.2014.12.001]
[http://dx.doi.org/10.1016/j.jocit.2014.12.001]
[32]
Wynn RF, Hart CA, Corradi-Perini C, et al. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood 2004; 104(9): 2643-5.
[http://dx.doi.org/10.1182/blood-2004-02-0526] [PMID: 15251986]
[http://dx.doi.org/10.1182/blood-2004-02-0526] [PMID: 15251986]
[33]
Chen Q, Shou P, Zhang L, et al. An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells. Stem Cells 2014; 32(2): 327-37.
[http://dx.doi.org/10.1002/stem.1567] [PMID: 24123709]
[http://dx.doi.org/10.1002/stem.1567] [PMID: 24123709]
[34]
De Becker A, Van Riet I. Homing and Migration of Mesenchymal Stromal Cells: How to Improve the Efficacy of Cell Therapy? World J Stem Cells 2016; 8(3): 73-87.
[http://dx.doi.org/10.4252/wjsc.v8.i3.73]
[http://dx.doi.org/10.4252/wjsc.v8.i3.73]
[35]
Capuco AV, Ellis SE, Hale SA, et al. Lactation persistency: Insights from mammary cell proliferation studies. J Anim Sci 2003; 81(Suppl. 3): 18-31.
[http://dx.doi.org/10.2527/2003.81suppl_318x] [PMID: 15000403]
[http://dx.doi.org/10.2527/2003.81suppl_318x] [PMID: 15000403]
[36]
Capuco AV, Choudhary RK, Daniels KM, Li RW, Evock-Clover CM. Bovine mammary stem cells: Cell biology meets production agriculture. Animal 2012; 6(3): 382-93.
[http://dx.doi.org/10.1017/S1751731111002369] [PMID: 22436217]
[http://dx.doi.org/10.1017/S1751731111002369] [PMID: 22436217]
[37]
Capuco A, Choudhary R. Symposium review: Determinants of milk production: Understanding population dynamics in the bovine mammary epithelium. J Dairy Sci 2020; 103(3): 2928-40.
[http://dx.doi.org/10.3168/jds.2019-17241] [PMID: 31704023]
[http://dx.doi.org/10.3168/jds.2019-17241] [PMID: 31704023]
[38]
Joshi PA, Jackson HW, Beristain AG, et al. Progesterone induces adult mammary stem cell expansion. Nature 2010; 465(7299): 803-7.
[http://dx.doi.org/10.1038/nature09091] [PMID: 20445538]
[http://dx.doi.org/10.1038/nature09091] [PMID: 20445538]
[39]
Annen EL, Collier RJ, McGuire MA, Vicini JL, Ballam JM, Lormore MJ. Effect of modified dry period lengths and bovine somatotropin on yield and composition of milk from dairy cows. J Dairy Sci 2004; 87(11): 3746-61.
[http://dx.doi.org/10.3168/jds.S0022-0302(04)73513-4] [PMID: 15483158]
[http://dx.doi.org/10.3168/jds.S0022-0302(04)73513-4] [PMID: 15483158]
[40]
Capuco AV, Evock-Clover CM, Minuti A, Wood DL. In vivo expansion of the mammary stem/progenitor cell population by xanthosine infusion. Exp Biol Med 2009; 234(4): 475-82.
[http://dx.doi.org/10.3181/0811-RM-320] [PMID: 19176874]
[http://dx.doi.org/10.3181/0811-RM-320] [PMID: 19176874]
[41]
Choudhary RK, Choudhary S, Verma R. In vivo response of xanthosine on mammary gene expression of lactating Beetal goat. Mol Biol Rep 2018; 45(4): 581-90.
[http://dx.doi.org/10.1007/s11033-018-4196-6] [PMID: 29804277]
[http://dx.doi.org/10.1007/s11033-018-4196-6] [PMID: 29804277]
[42]
Baldassarre H, Deslauriers J, Neveu N, Bordignon V. Detection of endoplasmic reticulum stress markers and production enhancement treatments in transgenic goats expressing recombinant human butyrylcholinesterase. Transgenic Res 2011; 20(6): 1265-72.
[http://dx.doi.org/10.1007/s11248-011-9493-y] [PMID: 21340524]
[http://dx.doi.org/10.1007/s11248-011-9493-y] [PMID: 21340524]
[43]
Choudhary RK, Capuco AV. In vitro expansion of the mammary stem/progenitor cell population by xanthosine treatment. BMC Cell Biol 2012; 13(1): 14.
[http://dx.doi.org/10.1186/1471-2121-13-14] [PMID: 22698263]
[http://dx.doi.org/10.1186/1471-2121-13-14] [PMID: 22698263]
[44]
Rambhatla L, Bohn SA, Stadler PB, Boyd JT, Coss RA, Sherley JL. Cellular senescence: ex vivo p53-dependent asymmetric cell kinetics. J Biomed Biotechnol 2001; 1(1): 28-37.
[http://dx.doi.org/10.1155/S1110724301000079] [PMID: 12488624]
[http://dx.doi.org/10.1155/S1110724301000079] [PMID: 12488624]
[45]
Paré J, Sherley J. Ex vivo expansion of human adult pancreatic cells with properties of distributed stem cells by suppression of asymmetric cell kinetics. J Stem Cell Res Ther 2013; 3(4): 149.
[http://dx.doi.org/10.4172/2157-7633.1000149] [PMID: 25197614]
[http://dx.doi.org/10.4172/2157-7633.1000149] [PMID: 25197614]
[46]
Lee HS, Crane GG, Merok JR, et al. Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK). Biotechnol Bioeng 2003; 83(7): 760-71.
[http://dx.doi.org/10.1002/bit.10727] [PMID: 12889016]
[http://dx.doi.org/10.1002/bit.10727] [PMID: 12889016]
[47]
Choudhary S, Li W, Bickhart D, et al. Examination of the xanthosine response on gene expression of mammary epithelial cells using RNA-seq technology. J Anim Sci Technol 2018; 60(1): 18.
[http://dx.doi.org/10.1186/s40781-018-0177-5] [PMID: 30009039]
[http://dx.doi.org/10.1186/s40781-018-0177-5] [PMID: 30009039]
[48]
Matulka LA, Triplett AA, Wagner K-U. Parity-induced mammary epithelial cells are multipotent and express cell surface markers associated with stem cells. Dev Biol 2007; 303(1): 29-44.
[http://dx.doi.org/10.1016/j.ydbio.2006.12.017] [PMID: 17222404]
[http://dx.doi.org/10.1016/j.ydbio.2006.12.017] [PMID: 17222404]
[49]
Boulanger CA, Wagner K-U, Smith GH. Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-β1 expression. Oncogene 2005; 24(4): 552-60.
[http://dx.doi.org/10.1038/sj.onc.1208185] [PMID: 15580303]
[http://dx.doi.org/10.1038/sj.onc.1208185] [PMID: 15580303]
[50]
Choudhary RK, Capuco AV. Expression of NR5A2, NUP153, HNF4A, USP15 and FNDC3B is consistent with their use as novel biomarkers for bovine mammary stem/progenitor cells. J Mol Histol 2021; 52(2): 289-300.
[http://dx.doi.org/10.1007/s10735-020-09948-8] [PMID: 33400051]
[http://dx.doi.org/10.1007/s10735-020-09948-8] [PMID: 33400051]
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