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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

ALK-阳性非小细胞肺癌； 潜在的联合药物治疗

卷 21, 期 9, 2021

发表于: 28 July, 2021

页: [737 - 748] 页: 12

弟呕挨: 10.2174/1568009621666210729100647

价格: $65

摘要

仅在过去几年中，染色体重排的 ALK 阳性非小细胞肺癌的进展非常显着。 由于引入了更有效的 ALK 抑制剂，存活时间显着提高。 这些改进主要是由于血脑屏障渗透的改进和药物有效对抗的配体结合口袋突变的广度。 然而，由于具有复合耐药突变的癌症的频率出现，进展可能缓慢，这表明需要开发多种 ALK 抑制剂来靶向不同的复合突变。另一个有望提供进一步收益的研究领域是使用药物组合，与 一种 ALK 抑制剂与一种针对“第二个驱动因素”的药物相结合，以克服耐药性。 在这篇综述中，对 ALK+ 肺癌的次要靶点范围及其临床成功的潜力进行了综述。

关键词: ALK 阳性 NSCLC、联合治疗、ALK 抑制剂、次要靶点、化合物耐药性、药物组合。

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