Recent Advancements in the Synthesis and Chemistry of Benzo-fused Nitrogen- and Oxygen-based Bioactive Heterocycles

Title:Recent Advancements in the Synthesis and Chemistry of Benzo-fused Nitrogen- and Oxygen-based Bioactive Heterocycles

Volume: 21 Issue: 17

Author(s): Ritu Sharma, Ravi K. Yadav, Richa Sharma, Nawal K. Sahu, Mukesh Jain and Sandeep Chaudhary*

Affiliation:

• Department of Chemistry, Laboratory of Organic and Medicinal Chemistry (OMC Lab), Malaviya National Institute of Technology Jaipur, Jawaharlal Nehru Marg, Jaipur-302017,India

Keywords: Benzo-fused, Heterocycles, Bioactive, Benzoxazinones, Spirooxindole, Coumarin, Benzopyran, 2H-indazole.

Abstract: Since a variety of benzo-fused nitrogen- and oxygen-based bioactive heterocyclic moieties are present in the form of benzoxazinones, spirooxindole-based heterocyclic compounds, coumarinfused heterocyclic compounds, and 2H-indazoles, this review article briefly describes some of the major advancements and developments in the area of 1,4-benzoxazine-3-ones, 1,4-benzoxazin-2- ones, spiropyrrolidine and spiropyrrolizine-based ring compounds, coumarin-fused compounds, benzopyran- fused coumarins and a 2H-indazoles class of bioheterocycles. Thus, keeping in view the medicinal importance of these bioactive benzo-fused heterocycles, special attention has been given to their synthesis as well as medicinal/pharmaceutical properties in detail.

Cite this article as:

Sharma Ritu , Yadav K. Ravi , Sharma Richa , Sahu K. Nawal , Jain Mukesh and Chaudhary Sandeep *, Recent Advancements in the Synthesis and Chemistry of Benzo-fused Nitrogen- and Oxygen-based Bioactive Heterocycles, Current Topics in Medicinal Chemistry 2021; 21 (17) . https://dx.doi.org/10.2174/1568026621666210715122919