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Review Article

PCSK9 在传染病中的作用

卷 29, 期 6, 2022

发表于: 14 July, 2021

页: [1000 - 1015] 页: 16

弟呕挨: 10.2174/0929867328666210714160343

价格: $65

摘要

背景：近年来，PCSK9 的生理作用的许多方面已被阐明，特别是关于其在脂质代谢、心血管风险中的作用以及其在先天免疫中的作用。越来越多的证据表明 PCSK9 参与病毒感染（主要是 HCV）的发病机制，以及调节宿主对细菌感染（主要是败血症和感染性休克）的反应。此外，PCSK9 的作用已被研究为疟疾感染发病机制和疾病严重程度的关键步骤。目的：本文的目的是回顾现有已发表的关于 PCSK9 在多种传染病中的作用的文献。结论：除了正在进行的关于在 HIV 感染患者中抑制 PCSK9 以治疗 HIV 和 ART 相关的高脂血症的研究外，临床前研究表明 PCSK9 如何参与减少 HCV 的复制。此外，还提出了 PCSK9 抑制对登革热和 SARS-CoV-2 病毒感染的保护作用。有趣的是，已在脓毒症患者中描述了高血浆 PCSK9 水平。最后，据报道 PCSK9 编码基因的功能丧失可能会降低疟疾感染的死亡率。

关键词: HCV、HIV、败血症、原虫感染、病毒感染、细菌感染、免疫。

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