摘要
含咖啡因饮料是全球消费最广泛的饮料,咖啡和茶是咖啡因最主要的两种来源。咖啡因含量因不同类型的饮料而异。除了咖啡因,咖啡和茶还有其他生物活性化合物,都可能影响一般和心血管(CV)健康。适度的咖啡因摄入(<300-400毫克/天),无论来源如何,都被欧洲和美国卫生当局认为是安全的,因为它与不良健康和CV影响无关,虽然它可以带来某些健康益处。咖啡摄入与CV风险之间存在非线性关联;适度喝咖啡与CV风险呈负相关,每天2-4杯最高益处,而大量饮用咖啡可能会增加风险。关于茶,由于每份咖啡因含量较低,其消费量仅受每日咖啡因总摄入量的限制。这两种含咖啡因的饮料,咖啡和茶,都含有额外的酚类化合物,具有抗氧化和抗炎活性,具有心脏保护作用。在几种咖啡化合物中,氯乙酸和类黑色素提供这种有益的作用,而二萜烯可能对脂质产生不利影响。大多数茶叶成分(多酚)都是心脏保护的。一个主要问题与能量饮料有关,其咖啡因含量要高得多,这使个人,特别是青少年和年轻人,处于高健康和CV风险中。本文讨论了所有这些问题,包括相关研究和荟萃分析,涉及的发病机制以及卫生当局的相关建议。
关键词: 咖啡,咖啡因,含咖啡因的饮料,心血管疾病,心律失常,心房颤动,心力衰竭,高血压。
[http://dx.doi.org/10.1111/j.1750-3841.2010.01561.x] [PMID: 20492310]
[http://dx.doi.org/10.1016/j.fct.2013.10.042] [PMID: 24189158]
[http://dx.doi.org/10.1016/j.fct.2004.05.002] [PMID: 15500929]
[http://dx.doi.org/10.1016/j.jada.2004.10.027] [PMID: 15635355]
[http://dx.doi.org/10.1080/0265203021000007840] [PMID: 12519715]
[http://dx.doi.org/10.1080/10408390903586412] [PMID: 21432699]
[http://dx.doi.org/10.3945/ajcn.111.023648] [PMID: 22338038]
[http://dx.doi.org/10.1080/10408390500400009] [PMID: 16507475]
[http://dx.doi.org/10.3390/nu11102377] [PMID: 31590412]
[http://dx.doi.org/10.1136/bmjdrc-2020-001252] [PMID: 33087342]
[http://dx.doi.org/10.1007/s10654-019-00524-3] [PMID: 31055709]
[http://dx.doi.org/10.3109/09637486.2014.940287] [PMID: 25046596]
[http://dx.doi.org/10.1080/07315724.2020.1827082] [PMID: 33216711]
[http://dx.doi.org/10.1161/CIRCULATIONAHA.113.005925] [PMID: 24201300]
[http://dx.doi.org/10.1007/s00394-017-1455-6] [PMID: 28424867]
[http://dx.doi.org/10.1093/jn/nxaa365] [PMID: 33382422]
[http://dx.doi.org/ 10.1093/advances/nmaa177] [PMID: 33570108]
[http://dx.doi.org/10.1016/B978-0-12-409517-5.00090-5]
[http://dx.doi.org/10.1007/978-3-642-13443-2_16] [PMID: 20859806]
[http://dx.doi.org/10.1161/01.HYP.17.2.117] [PMID: 1991645]
[http://dx.doi.org/10.1093/aje/153.4.353] [PMID: 11207153]
[http://dx.doi.org/10.1007/s13197-016-2378-6] [PMID: 28035147]
[http://dx.doi.org/10.1007/s00394-017-1379-1] [PMID: 28391515]
[http://dx.doi.org/10.1080/19390211.2017.1329244] [PMID: 28816550]
[http://dx.doi.org/10.1016/j.aninu.2020.01.001] [PMID: 32542190]
[http://dx.doi.org/10.3390/molecules26010085] [PMID: 33375458]
[http://dx.doi.org/10.7326/M16-2945] [PMID: 28693038]
[http://dx.doi.org/10.3177/jnsv.66.237] [PMID: 32612086]
[http://dx.doi.org/10.7326/M16-2472] [PMID: 28693036]
[http://dx.doi.org/10.1093/ajcn/nqy297] [PMID: 30838377]
[http://dx.doi.org/10.1093/advances/nmaa010] [PMID: 32073596]
[http://dx.doi.org/10.1002/mnfr.201900389] [PMID: 31216091]
[http://dx.doi.org/10.18632/oncotarget.23947] [PMID: 29765557]
[http://dx.doi.org/10.1016/j.ahj.2008.11.009] [PMID: 19249420]
[http://dx.doi.org/10.3945/ajcn.117.153338] [PMID: 28835365]
[http://dx.doi.org/10.1080/09637486.2020.1862069] [PMID: 33349068]
[http://dx.doi.org/10.1016/j.numecd.2020.07.016] [PMID: 33158718]
[http://dx.doi.org/10.1097/MCA.0000000000000397] [PMID: 27315099]
[http://dx.doi.org/10.1080/07315724.2006.10719561] [PMID: 17229893]
[http://dx.doi.org/10.1016/j.clnesp.2020.09.216] [PMID: 33183526]
[http://dx.doi.org/10.1002/ehf2.12684] [PMID: 32449612]
[http://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.967299] [PMID: 22740040]
[http://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.006799] [PMID: 33557575]
[http://dx.doi.org/10.3945/ajcn.111.016667] [PMID: 21880846]
[http://dx.doi.org/10.1177/1060028016656433] [PMID: 27340146]
[http://dx.doi.org/10.1007/s00394-017-1591-z] [PMID: 29222637]
[http://dx.doi.org/10.1016/j.clnu.2020.05.052] [PMID: 32576389]
[http://dx.doi.org/10.1016/j.clnu.2017.12.009] [PMID: 29331442]
[http://dx.doi.org/10.3945/ajcn.111.018267] [PMID: 22170367]
[http://dx.doi.org/10.1016/j.clnu.2016.03.021] [PMID: 27075317]
[http://dx.doi.org/10.1016/j.numecd.2020.08.017] [PMID: 33239163]
[http://dx.doi.org/10.1093/jn/nxaa212] [PMID: 32805014]
[http://dx.doi.org/10.1093/nutrit/nuy014] [PMID: 29590460]
[http://dx.doi.org/10.1111/ijcp.13983] [PMID: 33400346]
[http://dx.doi.org/10.1093/jn/nxz156] [PMID: 31396627]
[http://dx.doi.org/10.1161/JAHA.120.016808] [PMID: 33287642]
[http://dx.doi.org/10.3390/ijerph17155379] [PMID: 32722593]
[http://dx.doi.org/10.1039/D0FO01168A] [PMID: 32484174]
[http://dx.doi.org/10.1016/j.diabet.2015.09.001] [PMID: 26431818]
[http://dx.doi.org/10.1093/advances/nmaa132] [PMID: 33118010]
[http://dx.doi.org/10.1093/ajcn/81.3.578] [PMID: 15755825]
[http://dx.doi.org/10.1177/2047487315624524] [PMID: 26701875]
[http://dx.doi.org/10.3945/ajcn.2010.29627] [PMID: 20573799]
[http://dx.doi.org/10.1177/2047487318772945] [PMID: 29692210]
[http://dx.doi.org/10.4022/jafib.2205] [PMID: 31687073]
[http://dx.doi.org/10.1016/j.numecd.2019.07.015] [PMID: 31558414]
[http://dx.doi.org/10.1001/jamainternmed.2016.6374] [PMID: 27749954]
[http://dx.doi.org/10.1161/JAHA.115.002503] [PMID: 26813889]
[http://dx.doi.org/10.1136/heartjnl-2013-303950] [PMID: 24009307]
[http://dx.doi.org/10.1186/s12916-015-0447-8] [PMID: 26394673]
[http://dx.doi.org/10.1177/2047487320908385] [PMID: 32183549]
[http://dx.doi.org/10.1093/europace/euv261] [PMID: 26443445]
[http://dx.doi.org/10.4082/kjfm.2012.33.6.356] [PMID: 23267421]
[http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.105452] [PMID: 33188952]
[http://dx.doi.org/10.1016/j.amjcard.2006.06.058] [PMID: 17126666]
[http://dx.doi.org/10.3389/fnut.2017.00040] [PMID: 28868290]
[http://dx.doi.org/10.1155/2010/834060] [PMID: 21188209]
[http://dx.doi.org/10.1111/j.1365-2125.1983.tb01553.x] [PMID: 6871070]
[http://dx.doi.org/10.1172/JCI110124] [PMID: 7009653]
[http://dx.doi.org/10.1038/hr.2011.195] [PMID: 22072103]
[http://dx.doi.org/10.3390/nu11092104] [PMID: 31487926]
[http://dx.doi.org/10.1097/01.hjh.0000166828.94699.1d] [PMID: 15834273]
[http://dx.doi.org/10.1161/01.CIR.0000046228.97025.3A] [PMID: 12460875]
[http://dx.doi.org/10.1038/ejcn.2010.137] [PMID: 20664622]
[http://dx.doi.org/10.1038/ejcn.2010.9] [PMID: 20125186]
[http://dx.doi.org/10.3390/nu12061842] [PMID: 32575704]
[http://dx.doi.org/10.1089/jmf.2017.3935] [PMID: 28581877]
[http://dx.doi.org/10.2147/VHRM.S3055] [PMID: 19183744]
[http://dx.doi.org/10.1016/j.amjmed.2020.09.036] [PMID: 33130125]
[http://dx.doi.org/10.1186/1475-2891-10-93] [PMID: 21914162]
[http://dx.doi.org/10.1007/s00394-014-0763-3] [PMID: 25204719]
[http://dx.doi.org/10.1177/2047487320914443] [PMID: 32320635]
[http://dx.doi.org/10.1146/annurev.nutr.17.1.305] [PMID: 9240930]
[http://dx.doi.org/10.1016/j.nut.2013.01.003] [PMID: 23510568]
[http://dx.doi.org/10.1001/jama.1992.03480060057030] [PMID: 1732652]
[http://dx.doi.org/10.1080/10408398.2018.1489368] [PMID: 30614268]
[http://dx.doi.org/10.1080/10408398.2017.1360244] [PMID: 28812379]
[http://dx.doi.org/10.1016/j.jff.2013.12.006]
[http://dx.doi.org/10.1016/j.coph.2019.04.014] [PMID: 31102958]
[http://dx.doi.org/10.2165/00003088-200039020-00004] [PMID: 10976659]
[http://dx.doi.org/10.1155/2020/7909703] [PMID: 32775441]
[http://dx.doi.org/10.3390/molecules26010010] [PMID: 33375091]
[http://dx.doi.org/10.1016/j.ahj.2007.07.014] [PMID: 17892993]
[http://dx.doi.org/10.1007/s10654-016-0173-3] [PMID: 27372743]
[PMID: 31711152]
[http://dx.doi.org/10.1016/j.clnesp.2020.11.006] [PMID: 33487310]
[http://dx.doi.org/10.1007/s10654-014-9960-x] [PMID: 25354990]
[http://dx.doi.org/10.1016/j.ijcard.2014.12.176] [PMID: 26318390]
[http://dx.doi.org/10.1371/journal.pone.0103247] [PMID: 25079225]
[http://dx.doi.org/10.1039/D0FO02122A] [PMID: 33237083]
[http://dx.doi.org/10.1111/jce.13210] [PMID: 28387431]
[http://dx.doi.org/10.1016/j.ijcard.2011.10.017] [PMID: 22056042]
[http://dx.doi.org/10.1016/j.hrthm.2011.10.011] [PMID: 22001708]
[http://dx.doi.org/10.1016/j.ijcard.2012.03.095] [PMID: 22465350]
[http://dx.doi.org/10.5694/j.1326-5377.2009.tb02263.x] [PMID: 19120009]
[http://dx.doi.org/10.1161/CIRCULATIONAHA.111.057505] [PMID: 22451608]
[http://dx.doi.org/10.1016/j.fct.2021.111979] [PMID: 33450301]
[http://dx.doi.org/10.1007/s10840-019-00610-2] [PMID: 31482331]
[http://dx.doi.org/10.1542/peds.2011-0965] [PMID: 21624882]
[http://dx.doi.org/10.1016/j.tcm.2018.09.019] [PMID: 30301595]