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Review Article

癌症中的一氧化氮和免疫反应：寻找新的治疗策略

卷 29, 期 9, 2022

发表于: 07 July, 2021

页: [1561 - 1595] 页: 35

弟呕挨: 10.2174/0929867328666210707194543

价格: $65

摘要

近年来，人们越来越有兴趣了解一氧化氮 (NO) 的神秘功能以及这种多效性信号分子如何促进肿瘤发生。本综述试图揭示和讨论关于 NO 在癌症中的免疫调节作用的可用信息，以及 NO 供体在免疫治疗领域中作用的最新方法。为了实现这一目标，我们搜索了以下数据库，以确定有关经验证据的相关文献：Cochrane 图书馆、Pubmed、Medline 和 EMBASE 从 1980 年到 2020 年 3 月。已经做出了有价值的尝试来开发独特的基于 NO 的癌症疗法。尽管数据不允许一概而论，但证据似乎表明低/中等水平可能有利于肿瘤发生，而较高水平会发挥抗肿瘤作用。从这个意义上说，NO 供体的使用可能在免疫疗法中具有重要的治疗潜力，尽管目前还没有临床试验。对癌症中 NO 调节的免疫反应的新认识可能有助于揭示这把“双刃剑”在癌症生理和病理过程中的最新特征及其作为癌症治疗剂的潜在用途。简而言之，在这篇综述中，我们讨论了 NO 作为一种多效性信号分子参与癌症病理生理学的复杂细胞机制。我们还讨论了 NO 在癌症和肿瘤进展中的双重作用以及基于诱导型一氧化氮合酶 (iNOS) 治疗癌症的临床方法。

关键词: 一氧化氮、癌症、nNOS、iNOS、eNOS、免疫、多效性信号传导。

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