General Review Article

PCSK 9:炎症和动脉粥样硬化之间的联系

卷 29, 期 2, 2022

发表于: 07 July, 2021

页: [251 - 267] 页: 17

弟呕挨: 10.2174/0929867328666210707192625

价格: $65

摘要

前蛋白转化酶枯草杆菌蛋白酶/Kexin 9(PCSK 9)被揭示为脂质代谢的关键参与者,因此是动脉粥样硬化的发展和进展的关键参与者。PCSK 9与低密度脂蛋白(LDL)受体结合,诱导其降解,并增加血液循环LDL。因此,PCSK 9抑制剂由于其高度充分的LDL降低特性而代表了心血管风险降低疗法的重要支柱。虽然PCSK 9对脂质代谢的影响已被广泛研究,但PCSK 9的完整病理生理学谱尚未确定。他汀类药物已被证明具有有益的抗炎作用。在这种情况下,有证据表明PCSK 9也会干扰炎症过程,从而导致动脉粥样硬化的发展。由于脂质代谢本身会影响炎症过程,因此很难区分PCSK 9的脂质依赖性和独立性炎症特性。大量证据表明,PCSK9 LDL独立调节促炎细胞因子的分泌和血管壁中炎症的潜在途径,而最近的观察表明PCSK9还与凝集素样氧化LDL受体-1(LOX-1)相互作用,并通过降低LDL抑制炎症反应。总之,本综述提供了越来越多的证据表明PCSK9如何促进血管炎症和随后的动脉粥样硬化,以阐明PCSK9抑制剂在预防动脉粥样硬化中的抗炎作用。

关键词: PCSK9,炎症,脂质,低密度脂蛋白,动脉粥样硬化,心血管疾病 。

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