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Review Article

寡肽转运蛋白的表达、调控和作用：肿瘤中的 PEPT1

卷 29, 期 9, 2022

发表于: 07 July, 2021

页: [1596 - 1605] 页: 10

弟呕挨: 10.2174/0929867328666210707170214

价格: $65

摘要

PEPT1 是质子依赖性寡肽转运蛋白家族 (POT) 的重要成员。 许多研究证实，PEPT1在肠道吸收二肽、三肽和假肽方面发挥着关键作用。 近年来，多项研究发现PEPT1在恶性肿瘤组织和细胞中高表达。 PEPT1在肿瘤中的异常表达可能与肿瘤的进展密切相关，可作为恶性肿瘤诊断、治疗和预后的潜在分子标志物。 此外，PEPT1可用于介导抗肿瘤药物的靶向递送。 本文就近年来PEPT1在肿瘤中的表达、调控及作用进行综述。

关键词: 寡肽转运蛋白、PEPT1、SLC15A1、肿瘤、POT、PHT2。

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