Reduction of Oximes and Hydrazones: Asymmetric and Diastereoselective Approaches

Title:Reduction of Oximes and Hydrazones: Asymmetric and Diastereoselective Approaches

Volume: 25 Issue: 19

Author(s): João L.P. Ribeiro, Cláudia Alves, Ana L. Cardoso, Susana M.M. Lopes and Teresa M.V.D. Pinho e Melo*

Affiliation:

• University of Coimbra, Coimbra Chemistry Centre and Department of Chemistry, 3004-535 Coimbra,Portugal

Keywords: Chiral amines, asymmetric reduction, enantioselective reduction, diastereoselective reduction, oximes, chiral hydroxylamines, hydrazones, chiral hydrazines.

Abstract: The asymmetric reduction of oximes and hydrazones is an attractive and versatile strategy for the synthesis of chiral amines, which are valuable building blocks in organic synthesis. This review summarizes the relevant developments made in the last decade on the enantioselective and diastereoselective reduction of oximes and hydrazones involving metalcatalyzed hydrogenation/hydrogenolysis reactions, hydride donor reactions, and electrochemical reactions.

Cite this article as:

Ribeiro L.P. João , Alves Cláudia , Cardoso L. Ana , Lopes M.M. Susana and Pinho e Melo M.V.D. Teresa *, Reduction of Oximes and Hydrazones: Asymmetric and Diastereoselective Approaches, Current Organic Chemistry 2021; 25 (19) . https://dx.doi.org/10.2174/1385272825666210706151631