非乳酸及其衍生物的结构、合成及生物活性研究

Title:Structures, Synthesis and Biological Activities of Nonactic Acid and Its Derivatives

Volume: 28 Issue: 42

关键词: (±)-非乳酸、非肌动蛋白亚基、单酸、手性合成、生物活性、构效关系。

摘要: Nonactic acid, which is a macrocyclic nonactin subunit, contains four asymmetric centers and has the molecular formula of C10H18O3. Due to their various biological activities and challenging structural characteristics, nonactic acid and its derivatives have attracted much attention from scientists since 1955. These compounds possess significant antibacterial, insecticidal and acaricidal activities, as well as a promoting effect on plant growth. However, the studies in the anticancer activities of these compounds are limited. It is noticed that some derivatives of nonactic acid show significant cytotoxicity toward different human cancer cells, from which, a basic structure-activity relationship might be able to obtain. On the basis of these progresses, we believe that this review may provide new ideas for generating potent anticancer compounds bearing the same pharmacophores derived from those macrocyclic molecules.

Cite this article as:

Structures, Synthesis and Biological Activities of Nonactic Acid and Its Derivatives, Current Medicinal Chemistry 2021; 28 (42) . https://dx.doi.org/10.2174/0929867328666210628144347