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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

高脂肪饮食会加重 APP/PS1 小鼠的 AD 相关致病过程

卷 18, 期 4, 2021

发表于: 23 September, 2021

页: [310 - 325] 页: 16

弟呕挨: 10.2174/1567205018666210628100812

价格: $65

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摘要

背景：阿尔茨海默病 (AD) 是最常见的神经退行性疾病，消极的生活方式因素可能导致其发病。来自人类和小鼠模型的大量证据表明，与高脂肪饮食 (HFD) 相关的胰岛素抵抗 (IR) 会增加患 AD 和与年龄相关的淀粉样蛋白生成的风险。

目的：本研究的目的是证实和阐明 HFD 对 AD 模型小鼠淀粉样变性和认知缺陷的影响。

方法：我们在此表明，四个月的 HFD 喂养会增加 APP/PS1 小鼠（用作 AD 模型）的外周和大脑的 IR。同时，长期HFD会加剧APP/PS1小鼠的认知缺陷并损害树突完整性和突触蛋白的表达。此外，HFD 诱导 β-分泌酶 (BACE1) 表达增加和胰岛素降解酶 (IDE) 表达减少，导致 β-淀粉样蛋白 (Aβ) 积累。

结论：我们的数据表明，长期 HFD 伴随 IR 会促进 Aβ 毒性和认知缺陷，表明可改变的生活方式危害，如 HFD 诱导的 IR 可能有助于 AD 发病机制。

关键词: 阿尔茨海默病 (AD)、认知障碍、高脂肪饮食 (HFD)、胰岛素抵抗 (IR)、β-淀粉样蛋白 (Aβ)、胰岛素降解酶 (IDE)、β-分泌酶 (BACE1)。

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