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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

One-Pot Glycosylation Strategy for Rapid Access of Oligosaccharides with Wide Range of Molecular Diversity

Author(s): Rekha Sangwan and Pintu Kumar Mandala*

Volume 25, Issue 20, 2021

Published on: 25 June, 2021

Page: [2499 - 2541] Pages: 43

DOI: 10.2174/1385272825666210625121424

Price: $65

Abstract

In carbohydrate chemistry, the synthesis of complex saccharides with well-defined structures is the most formidable process as it is quite strenuous to isolate carbohydrates in acceptable purity and amounts from natural sources. Therefore, complex saccharides with well-defined structures are often most conveniently accessed through chemical syntheses. This review mainly focuses on the methodologies for one-pot glycosylation into the complex glycans from the non-reducing end to reducing end and vice versa, orthogonal, preactivation based, photochemical as well as hybrid one-pot glycosylation. The main goal of this review in the carbohydrate community was to rapidly synthesize biologically relevant glycans that can be implemented for research in carbohydrate-based vaccine development, diagnostics, as well as drug discovery.

Keywords: Glycosylation, one-pot, carbohydrate, oligosaccharide, orthogonal, preactivation.

Graphical Abstract


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