Abstract
The development of simple, atom-economical, and sustainable methodologies for the construction of various functional molecules from easily available substrates has been of great interest in synthetic chemistry. N,N-dimethylformamide (DMF) is an inexpensive, abundant solvent and industrial raw material, and it is considered as an effective polar solvent and also as a versatile reagent in synthetic transformations. During the past few decades, many significant and attractive achievements have been made in the fields of DMF as a reactant. The mini-review will mainly summarize recent advance in the applicants of DMF as a multipurpose building block in synthetic reactions.
Keywords: N, N-dimethylformamide, DMF, building block, organic solvent, versatile reactant, synthetic transformation, synthetic chemistry.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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