摘要
干细胞技术(例如治疗和诊断工具)的发展迅猛发展。干细胞衍生细胞目前用于各种临床试验。然而,所面临的关键问题和挑战涉及移植干细胞衍生细胞的低分化效率、整合和功能。骨髓、脂肪或其他间充质干细胞 (MSC) 的提取涉及侵入性方法、专业技能和昂贵的技术。另一方面,尿液来源的细胞是通过非侵入性方法获得的。可以从任何年龄的患者身上重复获取样本。尿液来源的细胞用于产生重编程或诱导多能干细胞 (iPSC),这些细胞可以培养并分化为各种类型的细胞谱系,用于使用人类疾病模型动物进行体外或体内生物医学研究和药物测试。尿液细胞衍生的 iPSCs (UiPSCs) 已成为具有巨大治疗意义的主要研究领域。鉴于初步临床前研究在安全性和作为再生工具方面取得成功,UiPSC 将为开发各种类型的自体干细胞疗法铺平道路。
关键词: 尿液细胞、干细胞、重编程、iPSC、再生医学、干细胞疗法。
Current Medicinal Chemistry
Title:Urine Cells-derived iPSCs: An Upcoming Frontier in Regenerative Medicine
Volume: 28 Issue: 31
关键词: 尿液细胞、干细胞、重编程、iPSC、再生医学、干细胞疗法。
摘要: There is a momentous surge in the development of stem cell technology, such as therapeutic and diagnostic tools. Stem cell-derived cells are currently used in various clinical trials. However, key issues and challenges faced involve the low differentiation efficiency, integration and functioning of transplanted stem cells-derived cells. Extraction of bone marrow, adipose or other mesenchymal stem cells (MSCs) involves invasive methods, specialized skills and expensive technologies. Urine-derived cells, on the other hand, are obtained by non-invasive methods; samples can be obtained repeatedly from patients of any age. Urine-derived cells are used to generate reprogrammed or induced pluripotent stem cells (iPSCs) which can be cultured and differentiated into various types of cell lineages for biomedical investigations and drug testing in vitro or in vivo using model animals of human diseases. Urine cells-derived iPSCs (UiPSCs) have emerged as a major area of research having immense therapeutic significance. Given that preliminary preclinical studies are successful in terms of safety and as a regenerative tool, the UiPSCs will pave the way to the development of various types of autologous stem cell therapies.
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Cite this article as:
Urine Cells-derived iPSCs: An Upcoming Frontier in Regenerative Medicine, Current Medicinal Chemistry 2021; 28 (31) . https://dx.doi.org/10.2174/0929867328666210623142150
DOI https://dx.doi.org/10.2174/0929867328666210623142150 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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