Abstract
Diabetes is a chronic non-communicable disease caused by several different routes, which has attracted increasing attention. In order to speed up the development of new selective drugs, machine learning (ML) technology has been applied in the process of diabetes drug development and opens up a new blueprint for drug design. This review provides a comprehensive portrayal of the application of ML in antidiabetic drug use.
Keywords: Antidiabetic drugs, mechanism of action, machine learning, hypoglycemic action, inhibitory activity, DPP-IV inhibitors.
[http://dx.doi.org/10.1152/physiol.00003.2018] [PMID: 29412061]
[http://dx.doi.org/10.1111/j.1464-5491.2007.02106.x] [PMID: 17367307]
[http://dx.doi.org/10.3390/pharmaceutics13030315] [PMID: 33670968]
[http://dx.doi.org/10.1111/dom.12978] [PMID: 28432751]
[http://dx.doi.org/10.7570/jomes20059] [PMID: 33071241]
[http://dx.doi.org/10.1038/s41573-019-0024-5] [PMID: 30976107]
[http://dx.doi.org/10.2515/therapie:2007051] [PMID: 17983557]
[http://dx.doi.org/10.2174/0929867053507298] [PMID: 15853709]
[http://dx.doi.org/10.1080/00325481.2020.1798099] [PMID: 32815454]
[http://dx.doi.org/10.4155/fmc-2016-0064] [PMID: 27357615]
[http://dx.doi.org/10.1073/pnas.94.9.4372] [PMID: 9113996]
[http://dx.doi.org/10.1096/fasebj.10.10.8751724] [PMID: 8751724]
[http://dx.doi.org/10.1016/j.carres.2013.07.008] [PMID: 23978663]
[http://dx.doi.org/10.4103/2230-8210.113725] [PMID: 23961473]
[http://dx.doi.org/10.1007/s11814-010-0280-x]
[http://dx.doi.org/10.1515/eng-2020-0029]
[http://dx.doi.org/10.1007/s11517-020-02132-w] [PMID: 32100174]
[http://dx.doi.org/10.1016/S0034-4257(03)00132-9]
[http://dx.doi.org/10.1007/s11554-019-00891-w]
[http://dx.doi.org/10.1109/TNN.1997.641482] [PMID: 18255760]
[http://dx.doi.org/10.1007/s10115-019-01335-4]
[http://dx.doi.org/10.1080/10803548.1998.11076397] [PMID: 10602625]
[http://dx.doi.org/10.1021/ci7003253] [PMID: 18183968]
[http://dx.doi.org/10.1021/mp100465q] [PMID: 21413792]
[http://dx.doi.org/10.1016/j.anucene.2019.107031]
[http://dx.doi.org/10.1021/cr2001355] [PMID: 21988241]
[http://dx.doi.org/10.1002/bkcs.10662]
[http://dx.doi.org/10.1124/pr.58.4.5] [PMID: 17132851]
[http://dx.doi.org/10.1007/s13300-018-0401-9] [PMID: 29536426]
[http://dx.doi.org/10.18520/cs/v111/i2/356-367]
[http://dx.doi.org/10.13005/ojc/340329]
[http://dx.doi.org/10.5530/ijper.53.3s.99]
[http://dx.doi.org/10.1002/dmrr.553] [PMID: 15852457]
[http://dx.doi.org/10.2337/diacare.26.10.2860] [PMID: 14514592]
[http://dx.doi.org/10.1078/0171-9335-00302] [PMID: 12647932]
[http://dx.doi.org/10.2337/dc13-2761] [PMID: 24742660]
[http://dx.doi.org/10.1016/S0140-6736(09)60659-0] [PMID: 19515413]
[http://dx.doi.org/10.1345/aph.1Q722] [PMID: 22669803]
[http://dx.doi.org/10.2147/DMSO.S231272] [PMID: 31920354]
[http://dx.doi.org/10.1016/j.diabres.2014.09.052] [PMID: 25458335]
[http://dx.doi.org/10.1111/jcpt.13134] [PMID: 32176827]
[http://dx.doi.org/10.2337/dc12-1333] [PMID: 23275363]
[http://dx.doi.org/10.1038/nsb882] [PMID: 12483204]
[http://dx.doi.org/10.1016/j.bbrc.2013.03.010] [PMID: 23501107]
[http://dx.doi.org/10.2174/156802605775009685] [PMID: 16375746]
[http://dx.doi.org/10.1111/j.1463-1326.2011.01414.x] [PMID: 21507182]
[http://dx.doi.org/10.1021/jm0493156] [PMID: 15634008]
[http://dx.doi.org/10.1016/j.bmc.2012.08.012] [PMID: 22959556]
[http://dx.doi.org/10.1007/s11255-016-1305-0] [PMID: 27193434]
[http://dx.doi.org/10.3803/EnM.2015.30.1.84] [PMID: 25325279]
[http://dx.doi.org/10.1111/j.2040-1124.2012.00221.x] [PMID: 24843615]
[http://dx.doi.org/10.1155/2017/5282343] [PMID: 29057274]
[PMID: 31618475]
[http://dx.doi.org/10.1007/s13300-018-0372-x] [PMID: 29435909]
[http://dx.doi.org/10.1080/10629360903278677] [PMID: 19916112]
[http://dx.doi.org/10.1007/s00894-009-0637-4] [PMID: 20069322]
[http://dx.doi.org/10.1007/s00894-007-0221-8] [PMID: 17618469]
[http://dx.doi.org/10.3109/14756361003777057] [PMID: 21299434]
[http://dx.doi.org/10.1007/s00044-013-0527-2]
[http://dx.doi.org/10.1155/2013/798743]
[http://dx.doi.org/10.1007/s11030-018-9815-6] [PMID: 29536226]
[http://dx.doi.org/10.1021/jm101016w] [PMID: 21186796]
[http://dx.doi.org/10.2174/092986712802002491] [PMID: 22709010]
[PMID: 28303056]
[http://dx.doi.org/10.1016/j.compbiolchem.2016.08.003] [PMID: 27570070]
[http://dx.doi.org/10.5530/ijper.51.4.98]
[http://dx.doi.org/10.1002/cmdc.200800213] [PMID: 18989859]
[http://dx.doi.org/10.1007/s10822-017-0009-6] [PMID: 28155089]
[http://dx.doi.org/10.1080/07391102.2017.1394221] [PMID: 29048995]
[http://dx.doi.org/10.1126/science.283.5407.1544] [PMID: 10066179]
[http://dx.doi.org/10.1021/bi035238p] [PMID: 14596593]
[http://dx.doi.org/10.1111/j.1745-7254.2006.00251.x] [PMID: 16364216]
[http://dx.doi.org/10.1111/cbdd.12135] [PMID: 23506477]
[http://dx.doi.org/10.1007/s00044-013-0690-5]
[http://dx.doi.org/10.1016/j.jmgm.2016.10.020] [PMID: 28006676]
[http://dx.doi.org/10.1071/CH12051]
[http://dx.doi.org/10.1016/j.chemolab.2016.06.002]
[http://dx.doi.org/10.1007/s40265-020-01278-z] [PMID: 32162273]
[http://dx.doi.org/10.1016/S0065-7743(06)41008-3]
[http://dx.doi.org/10.1111/cbdd.12683] [PMID: 26547388]
[http://dx.doi.org/10.5012/bkcs.2013.34.6.1643]
[http://dx.doi.org/10.1371/journal.pone.0102759] [PMID: 25047583]
[http://dx.doi.org/10.1016/j.compbiolchem.2018.07.019] [PMID: 30103106]
[http://dx.doi.org/10.1016/j.ejmech.2016.08.023] [PMID: 27560285]
[http://dx.doi.org/10.1016/j.ejmech.2019.112017] [PMID: 31926470]