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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Research Article

在her2阳性乳腺癌中，MALAT1促进肿瘤发生并增加细胞对赫赛汀的敏感性

卷 21, 期 10, 2021

发表于: 18 June, 2021

页: [860 - 869] 页: 10

弟呕挨: 10.2174/1568009621666210618164300

价格: $65

摘要

背景:MALAT1是一种长链非编码rna (lncRNA)，在HER2阳性乳腺癌中的作用仍有待进一步研究。 目的:本研究旨在探讨MALAT1对her2阳性乳腺癌肿瘤发展的影响。 方法:我们检测了MALAT1在her2阳性乳腺癌细胞和组织中的表达，并分析了MALAT1对her2阳性乳腺癌细胞株(BT-474和SKBR3)细胞增殖的影响。建立小鼠移植瘤模型，检测MALAT1在her2阳性乳腺癌中的作用。 结果表明，在her2阳性乳腺癌中，MALAT1在细胞和组织中均显著上调。此外，MALAT1的沉默抑制了her2阳性乳腺癌细胞在体外和体内的增殖。此外，在her2阳性乳腺癌细胞系和小鼠异种移植模型中，shRNA敲除MALAT1会下调DNMT1、DNMT3a和DNMT3b，而上调BRCA1和PTEN。 结论:总之，MALAT1可能是HER2阳性乳腺癌治疗的潜在生物标志物和治疗靶点。

关键词: her2阳性乳腺癌，长链非编码RNA, MALAT1, DNMTs，肿瘤发生，herceptin耐药。

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