Abstract
Radical chemistry is known for two centuries. Due to the fascinating nature of the radical-mediated processes, these reactions have attracted the attention of organic chemists to prepare new compounds with diverse stereochemistry. Radical-induced methods mostly follow atom economical principles. Tin-based radical annulation method is the most common and widely used procedure for the synthesis of a wide range of organic compounds with medicinal significance. In this review, we report recent stereoselective tin-mediated radical cyclization reactions. The versatility of tinbased reagents in the cyclization process as reported herein will encourage chemists to construct many other molecules of interest following the principles involved in these reactions.
Keywords: Carbon-carbon bond, tin, annulation, radical cyclization, stereochemistry, radical mediated.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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