1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review

Title:1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review

Volume: 21 Issue: 15

Author(s): Divya Sharma, Salahuddin*, Vikas Sharma, Rajnish Kumar, Sagar Joshi, Sunita Kumari, Shivani Saxena, Avijit Mazumder, Mohammad Shahar Yar and Mohamed Jawed Ahsan

Affiliation:

• Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306,India

Keywords: Cancer, 1, 3, 4-Oxadiazole, Anticancer potential, Synthetic methods, Receptors, Pharmacophore.

Abstract: Cancer is a kind of human cell degenerative disease that has affected many people for several years. Cancer is caused due to the abnormal growth of cells in every particular part of the body. The 1,3,4-oxadiazole ring is found to be a binding moiety that has anticancer potential. Various works on the 1,3,4-oxadiazole moiety showing anticancer activity have been reported. The present analysis summarizes general synthetic methods for 1,3,4 oxadiazole. Different receptors on which these drug acts are discussed. This review also presents pharmacophore models for topoisomerase-I, histone deacetylase, and epidermal growth factor enzymes.

Cite this article as:

Sharma Divya , Salahuddin *, Sharma Vikas , Kumar Rajnish , Joshi Sagar , Kumari Sunita , Saxena Shivani , Mazumder Avijit , Yar Shahar Mohammad and Ahsan Jawed Mohamed, 1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review, Current Topics in Medicinal Chemistry 2021; 21 (15) . https://dx.doi.org/10.2174/1568026621666210612031144