Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT)

Title: Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT)

Volume: 8 Issue: 3

Author(s): Xiang Zheng and Ravindra K. Pandey

Affiliation:

Keywords: Photodynamic therapy, Photofrin®, Porphyrin, Carbohydrate-Porphyrin Conjugates

Abstract: In recent years, a number or review articles describing the utility of porphyrin-based compounds in photodynamic therapy have been published.1 Currently, efforts are also underway in various laboratories to increase the tumor-specificity by developing targetspecific photosensitizers. One of such attempts has been to synthesize a series of carbohydrate-porphyrin conjugates and investigate their ability to target carbohydrate- recognized proteins, which are known for their high expression in certain tumors. The present article is focused on the synthesis and biological significance of carbohydrate conjugated photosensitizers.

Cite this article as:

Zheng Xiang and Pandey K. Ravindra, Porphyrin-Carbohydrate Conjugates: Impact of Carbohydrate Moieties in Photodynamic Therapy (PDT), Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (3) . https://dx.doi.org/10.2174/187152008783961897