Oxa-Michael Addition Reactions of 3-hydroxy-2-azetidinones: Synthesis of
1, 3, 4-Trisubstituted-2-Azetidinones

Priyanka       Sharma; Maninderjeet    Kaur    Mann; Gaurav       Bhargava

doi:10.2174/1570178618666210610155744

Abstract

The manuscript describes a facile and an efficient methodology for the synthesis of 1, 3, 4 trisubstituted-β-lactams by base mediated oxa-Michael addition reactions of 3-hydroxy-2- azetidinones with acetylenic esters under different reaction conditions. These functionalized 1, 3, 4-trisubstituted-azetidin-2-ones are useful organic synthons for the synthesis of various heterocyclic compounds having diverse pharmacological applications.

Keywords: Lactams, oxa-michael reaction, 3-hydroxy lactams, acetylenic ester, pharmacological applications, organic synthesis.

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DOI https://dx.doi.org/10.2174/1570178618666210610155744	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255

Letters in Organic Chemistry

Oxa-Michael Addition Reactions of 3-hydroxy-2-azetidinones: Synthesis of 1, 3, 4-Trisubstituted-2-Azetidinones

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