Abstract
Background: MicroRNAs (miRNA) belong to the substantial class of posttranscriptional gene regulators with decisive functions in typical cellular and disease progressions. They are short RNA molecules that are not translated into proteins but bind to the complementary sites of various mRNAs, thus blocking them and leading to translational inhibition.
Objective: These miRNA molecules act as signatory molecules or biomarkers for various types of malignancies. Different miRNAs are involved in different cancer-linked pathways depending on the nature, stage, and kind of cancer. The objective of this article is to discuss and review the role and significance of various miRNAs in two of the most prominent cancers; breast and ovarian cancer.
Methods: The role of miRNAs in the instigation, propagation, and metastasis of melanoma has been elucidated.
Results: This article focuses on the up- and down-regulation of various miRNAs in breast and ovarian cancer, with stress on diversity in their occurrence and specificity in their threshold levels in certain types and stages of cancer, suggesting their potential role as an effective diagnostic and treatment tool for cancer.
Conclusion: Considering all the aforementioned information, it can be concluded that miRNAs can act as potential biomarkers for the diagnosis of breast and ovarian cancers.
Keywords: Biomarker, cancer, diagnosis, translation, inhibition, gene regulation.
Graphical Abstract
Current Protein & Peptide Science
Title:MicroRNA, a Promising Biomarker for Breast and Ovarian Cancer: A Review
Volume: 22 Issue: 8
Author(s): Fatima Akram*, Noman Atique, Ikram ul Haq, Zeeshan Ahmed, Zuriat Jabbar, Ali Nawaz, Amna Aqeel and Rabia Akram
Affiliation:
- Institute of Industrial Biotechnology, GC University, Lahore-54000,Pakistan
Keywords: Biomarker, cancer, diagnosis, translation, inhibition, gene regulation.
Abstract:
Background: MicroRNAs (miRNA) belong to the substantial class of posttranscriptional gene regulators with decisive functions in typical cellular and disease progressions. They are short RNA molecules that are not translated into proteins but bind to the complementary sites of various mRNAs, thus blocking them and leading to translational inhibition.
Objective: These miRNA molecules act as signatory molecules or biomarkers for various types of malignancies. Different miRNAs are involved in different cancer-linked pathways depending on the nature, stage, and kind of cancer. The objective of this article is to discuss and review the role and significance of various miRNAs in two of the most prominent cancers; breast and ovarian cancer.
Methods: The role of miRNAs in the instigation, propagation, and metastasis of melanoma has been elucidated.
Results: This article focuses on the up- and down-regulation of various miRNAs in breast and ovarian cancer, with stress on diversity in their occurrence and specificity in their threshold levels in certain types and stages of cancer, suggesting their potential role as an effective diagnostic and treatment tool for cancer.
Conclusion: Considering all the aforementioned information, it can be concluded that miRNAs can act as potential biomarkers for the diagnosis of breast and ovarian cancers.
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Cite this article as:
Akram Fatima*, Atique Noman, Haq ul Ikram, Ahmed Zeeshan , Jabbar Zuriat, Nawaz Ali, Aqeel Amna and Akram Rabia, MicroRNA, a Promising Biomarker for Breast and Ovarian Cancer: A Review, Current Protein & Peptide Science 2021; 22 (8) . https://dx.doi.org/10.2174/1389203722666210608154705
DOI https://dx.doi.org/10.2174/1389203722666210608154705 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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