摘要
经过几十年的鉴定,许多过去和正在进行的研究都集中在β淀粉样蛋白切割酶1(BACE1)作为治疗阿尔茨海默病(AD)的靶标的治疗作用上。尽管在3期临床试验中最初的BACE1抑制剂大大减少了AD患者β淀粉样蛋白相关斑块,但研究人员最终因缺乏效力而停止了测试。这种停产导致针对BACE1的药物开发和发现有限,尽管对痴呆症和AD疗法的需求很高。因此,必须详细描述BACE1治疗方案在神经系统疾病中的潜在生物学基础。在这里,我们强调了BACE1的生物活性,遗传特性和在神经退行性治疗中的作用。我们回顾了BACE1外源结合抗体和变构抑制剂开发作为AD疗法的研究贡献。该评价还涵盖了BACE1生物学功能、疾病相关机制以及淀粉样蛋白前体蛋白位点分裂的酶条件。基于本综述,我们建议进一步研究抗BACE1外显性抗体和BACE1变构抑制剂。非活性位点抑制可能是阿尔茨海默氏症神经系统疾病BACE1治疗的前进方向。
关键词: BACE1生物学性质,阿尔茨海默病,BACE1外显性抗体,BACE1底物,基因表达,变构抑制剂。
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