Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry

Title:Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry

Volume: 21 Issue: 13

Author(s): Junjie Zhong, Wendi Xuan, Mengting Tang, Shihao Cui, Yuhang Zhou, Xiaosheng Qu*, Xin Cao*Bing Niu*

Affiliation:

• National Engineering Laboratory of Southwest Endangered Medicinal Resources Development, Guangxi Botanical Garden of Medicinal Plants, Nanning,China

• Zhongshan Hospital, Institute of Clinical Science, Shanghai Medical College, Fudan University, Shanghai,China

• School of Life Science, Shanghai University, 99 Shangda Road, Shanghai 200444,China

Keywords: Anoctamin 1, CaCCs, Cancer, Hypertension, Asthma, Pain, Heart disease, Diarrhea.

Abstract: ANO1, anoctamin 1(also known as TMEM16A), is the molecular basis of calcium-activated chloride channels with ten transmembrane segments which are widely expressed in mammalian cells, including epithelial cells, vascular smooth muscle tissues, electro-excitatory cells, and some tumor cells. To date, multiple studies have shown that many natural and synthetic compounds have regulatory effects on ANO1. Therefore, ANO1 could be a potential new drug target for the treatment of cancer, pain, diarrhea, hypertension, and asthma. In this study, we review the structure of ANO1 and its involvement in cancer, pain, diarrhea, hypertension, and asthma.

Cite this article as:

Zhong Junjie, Xuan Wendi, Tang Mengting, Cui Shihao, Zhou Yuhang, Qu Xiaosheng*, Cao Xin*, Niu Bing*, Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry, Current Topics in Medicinal Chemistry 2021; 21 (13) . https://dx.doi.org/10.2174/1568026621666210607125614