当前用于治疗胶质母细胞瘤的非病毒基因治疗策略

Title:Current Non-viral Gene Therapy Strategies for the Treatment of Glioblastoma

Volume: 28 Issue: 37

关键词: 胶质母细胞瘤、非病毒基因治疗、阳离子脂质、树枝状聚合物、树枝状移植物、聚合物胶束、聚（β-氨基酯）、睡美人转座子。

摘要:

Background: Glioblastoma constitutes the most frequent and aggressive primary malignant brain tumor in adults. Despite the advances in its treatment, its prognosis remains very poor. Gene therapy has been proposed as a complementary treatment since it may overcome the problem of the blood-brain barrier for systemic therapies, allowing to target tumor cells and their tumor microenvironment locally, without affecting the normal brain parenchyma. In comparison with viral vectors, non-viral vectors became an attractive tool due to their reduced potential of biosafety risks, lower cost, higher availability, and easy storage.

Objective: In this article, we aimed to outline the current preclinical and clinical developments of non-viral delivery systems for therapeutic transgene delivery in malignant gliomas.

Conclusion: Non-viral vectors are efficient tools for gene delivery since they exhibit reduced non-specific cytotoxicity and can go through several modifications in order to achieve high tumor tropism and the ability to cross the blood-brain barrier to access the tumor mass. However, further evaluations in preclinical models and clinical trials are required in order to translate it into the neuro-oncology clinic.

Cite this article as:

Current Non-viral Gene Therapy Strategies for the Treatment of Glioblastoma, Current Medicinal Chemistry 2021; 28 (37) . https://dx.doi.org/10.2174/0929867328666210525141243