摘要
背景:越来越多的证据表明miRs在调节细胞过程中具有关键作用,如细胞死亡、增殖和细胞周期。 引言:本研究旨在提供一个简明的综述关于肿瘤miRs和miRs与表观遗传因子之间的交叉对话的最新发现。 结果:miRs的表达水平与蛋白质编码基因一样,受多种转录网络的调控。事实上,miRs的表达可以被DNA甲基化因子和组蛋白修饰因子表观遗传调控。此外,miRs可以抑制调控表观遗传修饰的关键因子。此外,miRs还与癌症的发展、转移和化疗耐药有关。miRs的异常表达和miRs与表观遗传因子之间的异常调节回路参与了肿瘤的进展。 结论:识别肿瘤miRs可以为克服化疗耐药提供充分的机会,并为受影响的患者带来一线治疗。
关键词: 癌症,microRNA,表观遗传,调节回路,蛋白编码基因,肿瘤进展。
Current Medicinal Chemistry
Title:An Updated Review of the Cross-talk Between MicroRNAs and Epigenetic Factors in Cancers
Volume: 28 Issue: 42
关键词: 癌症,microRNA,表观遗传,调节回路,蛋白编码基因,肿瘤进展。
摘要:
Background: Growing evidence indicates that miRs have critical activities in adjusting cellular processes, e.g., cell death, proliferation, and cell-cycle.
Introduction: This study aimed to provide a concise review of the recent findings regarding tumoral miRs and the cross-talk between miRs and epigenetic factors.
Results: Like the protein-coding genes, the expression levels of miRs are mediated by various transcriptional networks. Indeed, the expression of miRs could be epigenetically modulated by DNA methylation factors and histone modifiers. Furthermore, miRs can suppress critical factors, which mediate epigenetic modifications. Besides, miRs have been implicated in cancer development, metastasis, and chemo-resistance. The aberrant expression of miRs and dysregulated modulatory circuits between miRs and epigenetic factors participate in tumor progression.
Conclusion: Identifying tumoral miRs can provide ample opportunity to overcome chemo- resistance and bring a forefront treatment for affected patients.
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Cite this article as:
An Updated Review of the Cross-talk Between MicroRNAs and Epigenetic Factors in Cancers, Current Medicinal Chemistry 2021; 28 (42) . https://dx.doi.org/10.2174/0929867328666210514125955
DOI https://dx.doi.org/10.2174/0929867328666210514125955 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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