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Review Article

多靶点定向配体是治疗阿尔茨海默病的有效策略

卷 29, 期 10, 2022

发表于: 04 January, 2022

页: [1757 - 1803] 页: 47

弟呕挨: 10.2174/0929867328666210512005508

价格: $65

摘要

阿尔茨海默病(AD)是一种复杂的神经系统疾病，多种病理因素被认为参与了该疾病的发生和进展。许多假说包括乙酰胆碱酯酶、单胺氧化酶、β-淀粉样蛋白、Tau蛋白等。已被提出为疾病的开始和进展。目前，乙酰胆碱酯酶抑制剂和美金刚胺(NMDAR拮抗剂)是唯一被批准的治疗AD症状管理的治疗方法。大多数这些单靶点药物在治疗或阻止疾病进展方面都惨败了。像AD这样的多因素疾病需要复杂的治疗策略，包括同时调节相互作用的靶点网络。近几年来，多靶点定向配体(MTDLs)策略，一种可以同时击中多个靶点的药物，正被探索为一种治疗AD的有效治疗方法。在目前的综述文章中，作者简要描述了与AD相关的各种致病途径。在最近报道的文章中，我们对多靶点定向配体的重要性及其设计策略进行了详细的讨论。本文描述了通过各种构效关系研究确定的有效先导物及其药物样特征。本文综述了最近开发出的有前景的化合物。其中一些对不同靶点具有平衡活性的MTDL有可能被开发为治疗AD的候选药物。

关键词: 阿尔茨海默病，乙酰胆碱酯酶，单胺氧化酶，β-淀粉样蛋白，多靶点定向配体，多靶点定向配体

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