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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Uncatalyzed Synthesis of Unsymmetrical Indole-substituted Methane Derivatives via One-pot Multicomponent Reactions under Solvent-free Conditions

Author(s): Shiyin Li, Xinru Lin, Xiling Gao, Wangyu Zeng, Xiaoyi Wu, Xuan Shi, Shengjie Chen and Yan Zhang*

Volume 19, Issue 3, 2022

Published on: 08 May, 2021

Page: [190 - 197] Pages: 8

DOI: 10.2174/1570178618666210508234339

Price: $65

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Abstract

For the first time, one-pot multicomponent reactions containing indole, aromatic aldehydes, and dimedone have been achieved in the absence of a catalyst under solvent-free conditions. A class of unsymmetrical indole-substituted methane derivatives and symmetrical diindolylmethanes has been synthesized through this green organic synthetic method. Based on experimental results, a reasonable mechanism for this condensation is emphasized here.

Keywords: Indole, aldehydes, unsymmetrical, multi-component reactions, solvent-free, green.

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