Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources

Title:Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources

Volume: 19 Issue: 11

Author(s): Abdul Jalil Shah, Reyaz Hassan Mir , Roohi Mohi-ud-din *, Faheem Hyder Pottoo, Mubashir Hussain Masoodi*Zulfiqar Ali Bhat*

Affiliation:

• Pharmacognosy Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, 190006, Kashmir,India

• Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar- 190006, Kashmir,India

• Pharmacognosy Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, 190006, Kashmir,India

Keywords: Antidepressants, plant-derived natural compounds, CNS, neurotransmitters, BDNF, monoamines.

Abstract: Depression, a well-known mental disorder, has global prevalence, affecting nearly 17% of the population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main sources for new drug candidates of depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic systems, and elevation of BDNF levels. The focus of this article is to review the role of signalling molecules in depression and highlight the use of plant-derived natural compounds to counter CNS depression.

Cite this article as:

Shah Jalil Abdul , Mir Hassan Reyaz , Mohi-ud-din Roohi *, Pottoo Hyder Faheem , Masoodi Hussain Mubashir *, Bhat Ali Zulfiqar *, Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources, Current Neuropharmacology 2021; 19 (11) . https://dx.doi.org/10.2174/1570159X19666210426115234